Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure.
Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure.
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DOI：
10.1089/ars.2007.1949
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发表时间：
2008-02
影响因子：
6.6
通讯作者：
Ken-ichi Takahashi;K. Chin;Hajime Nakamura;S. Morita;Kensuke Sumi;T. Oga;H. Matsumoto;A. Niimi;S. Fukuhara;J. Yodoi;M. Mishima
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文献类型：
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作者：
Ken-ichi Takahashi;K. Chin;Hajime Nakamura;S. Morita;Kensuke Sumi;T. Oga;H. Matsumoto;A. Niimi;S. Fukuhara;J. Yodoi;M. Mishima
阻塞性睡眠呼吸暂停（OSA）与心血管死亡率增加有关，氧化应激被认为起着重要作用。我们假设，血浆TRX水平，一种新的氧化应激标志物，在OSA患者中升高。血浆TRX和脂联素水平，这是显着相关的心血管死亡率，在41例重度OSA患者前（n = 41）和后（n = 27）鼻持续气道正压通气治疗（nCPAP）1个月和12例无OSA（非OSA组）的受试者。与非OSA组相比，OSA组的TRX水平显著较高（p = 0.02），脂联素水平显著较低（p = 0.02）。nCPAP治疗1个月后（n = 27），TRX水平显著降低（p = 0.03），脂联素水平显著升高（p = 0.03）。在14名未经治疗的OSA患者中，TRX和脂联素水平在1个月内没有显著变化。在53例（41例OSA + 12例非OSA）受试者中，TRX水平与呼吸紊乱指数（p = 0.001）和SaO（2）<90%的时间百分比（p = 0.0002）呈正相关。脂联素水平，而不是TRX水平，与BMI相关（n = 53; p = 0.02）。血浆TRX可能是评估OSA患者氧化应激和监测nCPAP有效性的独特标志物。
Obstructive sleep apnea (OSA) is associated with increased cardiovascular mortality, and oxidative stress was suggested to play an important role. We hypothesized that the plasma TRX level, a novel oxidative stress marker, is elevated in OSA patients. Plasma TRX and adiponectin levels, which are significantly associated with cardiovascular mortality, were measured in 41 patients with severe OSA before (n = 41) and after (n = 27) nasal continuous positive airway pressure therapy (nCPAP) for 1 month and in 12 subjects without OSA (non-OSA group). The TRX level was significantly higher (p = 0.02) and the adiponectin level was significantly lower (p = 0.02) in the OSA group than in the non-OSA group. After 1 month of nCPAP (n = 27), the TRX level significantly decreased (p = 0.03), and the adiponectin level significantly increased (p = 0.03). Among the 14 patients with untreated OSA, the TRX and adiponectin levels did not significantly change over a 1-month interval. Among the 53 (41 OSA + 12 non-OSA) subjects, the TRX level was positively correlated with the respiratory disturbance index (p = 0.001) and percentage of time with SaO(2) <90% (p = 0.0002). The adiponectin level, but not the TRX level, was correlated with the BMI (n = 53; p = 0.02). Plasma TRX may be a unique marker for evaluating oxidative stress and monitoring the effectiveness of nCPAP in OSA patients.