Physiological Significance of Resistin and Resistin-Like Molecules in the Inflammatory Process and Insulin Resistance
Physiological Significance of Resistin and Resistin-Like Molecules in the Inflammatory Process and Insulin Resistance
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DOI：
10.2174/1573399810602040449
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发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Uchijima, Yasunobu
中科院分区：
文献类型：
--
作者：
Asano, Tomoichiro;Sakosda, Hideyuki;Uchijima, Yasunobu
抵抗素最初被认为是一种由脂肪细胞分泌的蛋白质，可以抑制胰岛素的作用和脂肪的分化。这三种与抵抗素同源的蛋白被称为抵抗素样分子（resistin-like molecules， RELM）。抵抗素和RELM在脂肪中大量表达，但RELM和RELM主要由肠道分泌。最近，抵抗素和relm被报道与炎症有关。例如，RELM被视为一种炎症相关蛋白，最初是在实验诱导的肺部炎症动物的支气管肺泡灌洗液中发现的。RELM也与细菌定植有关，但RELM注射或肝脏过表达RELM可诱导胰岛素抵抗。从大鼠鼻呼吸上皮中分离的RELM被发现受到香烟烟雾的改变。因此，抵抗素和relm可用于评估体内炎症状况。另一方面，血清抵抗素或RELM浓度是否与胰岛素抵抗密切相关尚不清楚。然而，考虑到最近的研究显示炎症与糖尿病胰岛素抵抗之间的密切关系，这些蛋白可能在炎症和胰岛素抵抗之间具有相互作用，两者都主要参与动脉粥样硬化的进展。如果是这样，血清抵抗素或RELM浓度可能是动脉粥样硬化风险的良好标志。此外，这些蛋白或未知受体是治疗糖尿病和预防动脉粥样硬化的潜在治疗靶点。这些可能性值得进一步研究。
Resistin was initially identified as a protein, secreted by adipocytes, which inhibits insulin action and adipose differentiation. The three proteins homologous to resistin were termed resistin-like molecules ( RELM), and. Resistin and RELM are abundantly expressed in adipose, but RELM and RELM are secreted mainly from the gut.Recently, resistin and RELMs were reported to be associated with inflammation. For example, RELM, viewed as an inflammation-related protein, was originally identified in broncho-alveolar lavage fluid obtained from animals with experimentally induced pulmonary inflammation. RELM is also related to bacterial colonization, but RELM injection or hepatic overexpression of RELM induced insulin resistance. RELM isolated from rat nasal respiratory epithelium was found to be altered by cigarette smoke. Thus, resistin and RELMs could be useful for assessing the inflammatory condition in vivo.On the other hand, whether the serum resistin or RELM concentration is strongly related to insulin resistance remains unclear. However, taking recent studies showing a close relationship between inflammation and insulin resistance in diabetes into consideration, these proteins may have interactive roles linking inflammation and insulin resistance, both of which major involvement in the progression of atherosclerosis. If so, the serum resistin or RELM concentration may be a good marker of atherosclerotic risk. In addition, these proteins or unidentified receptors are potential therapeutic targets for the treatment of diabetes and prevention of atherosclerosis. These possibilities merit further study.