The diversity of lobula plate tangential cells (LPTCs) in the Drosophila motion vision system.
The diversity of lobula plate tangential cells (LPTCs) in the Drosophila motion vision system.
复制标题
果蝇运动视觉系统中小叶板切向细胞（LPTC）的多样性。
DOI：
10.1007/s00359-019-01380-y
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Desplan,Claude
中科院分区：
文献类型：
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作者：
Wei,Huayi;Kyung,HaYoung;Kim,PriscillaJ;Desplan,Claude
为了在环境中导航，动物依靠视觉反馈来控制它们相对于周围环境的运动。在双翅目果蝇中，视觉反馈由视觉系统中称为小叶板切向细胞（LPTC）的广域运动敏感神经元提供。了解 LPTC 在果蝇行为中的作用可以解决许多关于感觉回路如何引导行为的基本问题。据估计，苍蝇有约 60 个 LPTC，但在果蝇中只发现了少数。我们进行了 Gal4 驱动程序筛选，并根据其形态特征识别了果蝇的五种 LPTC 亚型：LPTC 在小叶板中具有较大的树枝状结构，并投射到中央大脑。我们将它们的形态与绿蝇 LPTC 进行了比较，并以最相似的绿蝇细胞命名它们：CH、H1、H2、FD1 和 FD3 以及 V1。我们进一步表征了它们的突触前和突触后组织，以及它们的神经递质概况。这些解剖学特征在很大程度上与它们可能的苍蝇对应物的解剖学和功能一致。然而，一些解剖学细节表明果蝇LPTC 可能具有更复杂的功能。我们对果蝇中这五种 LPTC 的表征将有助于进一步的功能研究，以了解它们在指导果蝇行为的视觉回路中的作用。
To navigate through the environment, animals rely on visual feedback to control their movements relative to their surroundings. In dipteran flies, visual feedback is provided by the wide-field motion-sensitive neurons in the visual system called lobula plate tangential cells (LPTCs). Understanding the role of LPTCs in fly behaviors can address many fundamental questions on how sensory circuits guide behaviors. The blowfly was estimated to have ~ 60 LPTCs, but only a few have been identified inDrosophila. We conducted a Gal4 driver screen and identified five LPTC subtypes inDrosophila, based on their morphological characteristics: LPTCs have large arborizations in the lobula plate and project to the central brain. We compared their morphologies to the blowfly LPTCs and named them after the most similar blowfly cells: CH, H1, H2, FD1 and FD3, and V1. We further characterized their pre- and post-synaptic organizations, as well as their neurotransmitter profiles. These anatomical features largely agree with the anatomy and function of their likely blowfly counterparts. Nevertheless, several anatomical details indicate theDrosophilaLPTCs may have more complex functions. Our characterization of these five LPTCs inDrosophilawill facilitate further functional studies to understand their roles in the visual circuits that instruct fly behaviors.