Effect of pentoxifylline on veno-occlusive priapism-induced corporeal tissue lipid peroxidation in a rat model
Effect of pentoxifylline on veno-occlusive priapism-induced corporeal tissue lipid peroxidation in a rat model
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DOI：
10.1007/bf01037931
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发表时间：
1997-04-01
影响因子：
--
通讯作者：
Kaya, B
中科院分区：
文献类型：
--
作者：
Evliyaoglu, Y;Kayrin, L;Kaya, B
目标：探讨是否可以发挥作用，在衰减缺血/再灌注对皮质组织的有害影响，在大鼠模型的静脉闭塞性阴茎异常勃起（VOP.Materials and Methods）：安慰剂和pendrifylline给予8组大鼠阴茎异常勃起被诱导的持续时间为6和12小时，分别由真空收缩装置。一半的大鼠组，经历了相同的持续时间的阴茎异常勃起（缺血性）进行1小时的消肿后带去除（再灌注）。一组不进行操作，也不给药，并作为基线测定（对照）。结果：VOP大鼠脑组织MDA含量与对照组比较有显著性差异（P < 0.001），而单纯缺血组与再灌注组比较无显著性差异（P > 0.05）。在喷替茶碱预处理组，虽然MDA积累往往是略低于安慰剂组，差异无统计学意义（P > 0.05），无论是在6或12小时持续阴茎异常勃起groups.Conclusions：LP，自由基氧代谢产物（ROM）诱导的损伤的指标，发生在大鼠皮质组织中的VOP废除期间和之后。单剂量的喷替茶碱预处理未能对VOP大鼠模型中的皮质组织在LP衰减方面发挥保护作用。
Objective: To investigate whether pentoxifylline could play a role in attenuation of the hazardous effects of ischemia/reperfusion on corporeal tissue in a rat model of veno-occlusive priapism (VOP).Materials and methods: Placebo and pentoxifylline were given to eight groups of rats prior to priapism being induced by a vacuum constrictive device for durations of 6 and 12 h, respectively. Half of the groups of rats that underwent the same duration of priapism (ischemic) were subjected to 1 h of detumescence after band removal (reperfusion). One group underwent no manipulation and no drug: administration and served as a baseline determination (control). Corporeal homogenates were examined for lipid peroxidation (LP) derived malondialdehyde (MDA) accumulation via thiobarbituric acid assay.Results: MDA concentration differed significantly between VOP rats and controls (P < 0.001) but did not differ significantly between ischemic-only groups and reperfused groups (P > 0.05). In the pentoxifylline-pretreated groups, although MDA accumulation tended to be slightly lower than in the placebo groups, the difference was not statistically significant (P > 0.05) either in the 6- or 12-h duration priapic groups.Conclusions: LP, an indicator of radical oxygen metabolite (ROM) induced injury, occurs in rat corporeal tissue during and after abolishment of VOP. Single-dose pentoxifylline pretreatment failed to exert a protective effect on corporeal tissue in a rat model of VOP in terms of attenuation of LP.