Meta-analyses of the associations of respiratory health effects with dampness and mold in homes
Meta-analyses of the associations of respiratory health effects with dampness and mold in homes
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DOI：
10.1111/j.1600-0668.2007.00475.x
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发表时间：
2007-08-01
期刊：
影响因子：
5.8
通讯作者：
Mendell, M. J.
中科院分区：
文献类型：
--
作者：
Fisk, W. J.;Lei-Gomez, Q.;Mendell, M. J.
美国国家科学院医学研究所（TOM）最近完成了对有关室内潮湿和霉菌污染与不良健康影响之间关系的科学文献的严格审查。在本文中，我们报告了TOM报告中回顾的研究以及其他相关研究的定量荟萃分析结果。我们开发了比值比（OR）的点估计值和置信区间（CI），这些比值比总结了几种呼吸和哮喘相关的健康结果与家中潮湿和霉菌的存在之间的关系。将原始研究的OR和CI转换为对数尺度，并将随机效应模型应用于对数OR及其方差。模型解释了分析的研究中多个结果之间的相关性。健康结局OR的中心估计值范围为1.34 - 1.75。CI（95%）在9/10例中排除了1，并且在大多数情况下CI的下限超过1.2。根据荟萃分析的结果，建筑物潮湿和霉菌与各种呼吸和哮喘相关健康结果增加约30-50%相关。
The Institute of Medicine (TOM) of the National Academy of Sciences recently completed a critical review of the scientific literature pertaining to the association of indoor dampness and mold contamination with adverse health effects. In this paper, we report the results of quantitative meta-analyses of the studies reviewed in the TOM report plus other related studies. We developed point estimates and confidence intervals (CIs) of odds ratios (ORs) that summarize the association of several respiratory and asthma-related health outcomes with the presence of dampness and mold in homes. The ORs and CIs from the original studies were transformed to the log scale and random effect models were applied to the log ORs and their variance. Models accounted for the correlation between multiple results within the studies analyzed. Central estimates of ORs for the health outcomes ranged from 1.34 to 1.75. CIs (95%) excluded unity in nine of 10 instances, and in most cases the lower bound of the CI exceeded 1.2. Based on the results of the meta-analyses, building dampness and mold are associated with approximately 30-50% increases in a variety of respiratory and asthma-related health outcomes.