Serotonin 5-HT1A and 5-HT3 Receptors in an Impulsive-Aggressive Phenotype
Serotonin 5-HT1A and 5-HT3 Receptors in an Impulsive-Aggressive Phenotype
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DOI：
10.1037/a0015333
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发表时间：
2009-06-01
影响因子：
1.9
通讯作者：
Delville, Yvon
中科院分区：
文献类型：
--
作者：
Cervantes, M. Catalina;Delville, Yvon
在成年雄性仓鼠中，攻击性攻击的个体差异与冲动选择和5-羟色胺(5-HT)神经支配的差异相关。由于5-羟色胺1A(5-羟色胺1A)受体参与抑制攻击，而5-羟色胺(3)受体激活促进攻击，作者假设它们表达的差异与行为的差异有关。作者使用不同延迟的延迟折扣范式证实了之前的行为关联，因为与低攻击性(L-Agg)仓鼠相比，高攻击性(H-Agg)仓鼠在大多数延迟下更喜欢即时奖赏杠杆而不是延迟奖赏杠杆。虽然作者在H-Agg仓鼠的几个区域观察到较高密度的5-羟色胺(1A)受体免疫反应性，但这似乎与缺乏5-羟色胺释放有关，进一步观察到氟西汀治疗的仓鼠核周和5-羟色胺(1A)受体免疫反应减少。此外，在选定区域内，H-Agg仓鼠的5-HT3受体密度较高。这些数据表明，冲动和攻击性特征集中在一个与5-羟色胺功能的各个方面相关的表型上，例如5-羟色胺的释放和5-羟色胺(1A)和5-羟色胺(3)受体的差异表达。
In adult male hamsters, individual differences in offensive aggression are correlated with differences in impulsive choice and decreased serotonin (5-HT) innervation. As serotonin 1A (5-HT(1A)) receptors participate in the inhibition of aggression, whereas 5-HT(3) receptor activation facilitates aggression, the authors hypothesized that differences in their expression are associated with differences in behavior. The authors confirmed previous behavioral associations, using a delay-discounting paradigm with various delays, as high-aggression (H-Agg) hamsters preferred the immediate-reward lever over the delayed-reward lever under most delays, compared with low-aggression (L-Agg) hamsters. Although the authors observed a greater density of 5-HT(1A) receptor immunoreactivity in H-Agg hamsters within several areas, it appears to be related to a lack of serotonin release, as supported by further observations of decreased immunoreactive perikarya and 5-HT(1A) receptors in fluoxetine-treated hamsters. Also, 5-HT3 receptor density was greater in H-Agg hamsters within select areas. The data indicate a convergence of impulsive and aggressive characteristics to one phenotype that is associated with various aspects of serotonin function, such as serotonin release and differential expression of 5-HT(1A) and 5-HT(3) receptors.