Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects
Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects
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DOI：
10.1016/j.biopsych.2004.12.026
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发表时间：
2005-03-01
影响因子：
10.6
通讯作者：
Stern, E
中科院分区：
文献类型：
--
作者：
Protopopescu, X;Pan, H;Stern, E
背景：先前的神经影像学研究表明，创伤后应激障碍（PTSD）患者的杏仁核对负面刺激的反应夸大。这种杏仁核反应的时间过程在很大程度上尚未研究，它与PTSD暴露治疗中的习惯化和致敏问题有关。方法：应用血氧依赖功能磁共振成像和统计参数作图技术，研究性/肢体虐待PTSD患者和正常对照组的杏仁核对创伤相关和非创伤相关情绪词的反应。我们通过对早期和晚期的单独分析来考察这种反应的时间进程。结果：与正常对照相比，创伤后应激障碍受试者对创伤相关负性刺激的初始杏仁核反应相对增加，而非创伤相关负性刺激的初始杏仁核反应相对增加。患者也不能表现出对不同类型的负面刺激的正常敏化和习惯化模式。这些发现与测量的PTSD症状严重程度相关。结论：我们的研究结果表明，创伤后应激障碍和正常对照组的杏仁核对情绪和控制刺激的反应具有不同的时间过程和特异性。这对创伤后应激障碍的病理生理模型和治疗反应具有启示意义。结果也延伸了先前的神经成像研究，证明PTSD患者的杏仁核相对增加，并将这些结果扩展到主要是女性患者群体，并对其进行了情感化的研究。
Background: Previous neuroiniaging studies have demonstrated exaggerated amygdala response to negative stimuli in postraumatic stress disorder (PTSD). The time course of this amygdala response is largely unstudied and is relevant to questions of habituation and sensitization in PTSD exposure therapy.Methods: We applied blood oxygen level dependent functional magnetic resonance imaging and statistical parametric mapping to study amygdala responce to trauma-related and nontrauma-related emotional words in sexual/physical abuse PTSD and normal control subjects. We examined the time course of this responce by separate analysis of early and late epochs.Results: PTSD versus normal control subjects have a relatively increased initial amygdala response to trauma-relatcd negative, but not nontramna-related negative, versus neutral stimuli. Patients also fail to show the normal patterns of sensitization and habituation to different categories of negative stimuli. These findings correlate with measured PTSD symptom severity.Conclusions: Our results demonstrate differential time courses and specificity of amygdala response to emotional and control stimuli in PTSD and normal control subjects. This has implications for pathophysiologic models of PTSD and treatment response. The results also extend previous neuroimaging studies demonstrating relatively increased amygdala in PTSD and expand these results to a largely female patient population probed with emotionally valenced words.