Social status does not predict responses to Seoul virus infection or reproductive success among male Norway rats
Social status does not predict responses to Seoul virus infection or reproductive success among male Norway rats
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DOI：
10.1016/j.bbi.2005.06.003
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发表时间：
2006-03
期刊：
影响因子：
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通讯作者：
E. R. Hinson;Michele F. Hannah;D. Norris;G. Glass;S. Klein
中科院分区：
文献类型：
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作者：
E. R. Hinson;Michele F. Hannah;D. Norris;G. Glass;S. Klein
在用于增加生存和繁殖的生活史策略之间存在权衡；因此，参与更多竞争行为的男性可能更容易受到感染。汉坦病毒在啮齿动物之间的水平传播是通过唾液中的病毒传播，雄性啮齿动物比雌性啮齿动物更容易感染汉坦病毒。为了确定在优势和对首尔病毒感染的易感性之间是否存在权衡，将雄性Long Evans大鼠与雌性大鼠分组饲养(3只/笼)，并在10天的群养条件下观察攻击性和从属行为。在行为测试后，男性被单独安置，接种首尔病毒，并收集血液、唾液和粪便样本。支配地位的雄性比从属的雄性发起更具攻击性的交锋。然而，优势男性和从属男性在感染过程中有相似的类固醇激素浓度、抗首尔病毒免疫球蛋白反应和体重增加。在感染期间，占主导地位和从属地位的男性在唾液和粪便中传播病毒的比例相似。利用微卫星DNA标记，将亲子关系分配给在群体收容期内出生的幼崽。与我们最初的假设相反，占主导地位和从属地位的雄性繁殖出的幼崽比例相似。综上所述，宿主的社会地位可能不能预测在啮齿动物水库种群中的繁殖成功或对汉坦病毒的易感性。
Trade-offs exist among life history strategies that are used to increase survival and reproduction; such that, males that engage in more competitive behaviors may be more susceptible to infection. Hantaviruses are transmitted horizontally between rodents through the passage of virus in saliva during wounding and male rodents are more likely to be infected with hantaviruses than females. To determine whether a trade-off exists between dominance and susceptibility to Seoul virus infection, male Long Evans rats were group housed (3/cage) with a female rat and aggressive and subordinate behaviors were monitored during a 10 day group housing condition. After behavioral testing, males were individually housed, inoculated with Seoul virus, and blood, saliva, and fecal samples were collected. Dominant males initiated more aggressive encounters than subordinate males. Dominant and subordinate males, however, had similar steroid hormone concentrations, anti-Seoul virus IgG responses, and weight gain over the course of infection. A similar proportion of dominant and subordinate males shed virus in saliva and feces during infection. Using microsatellite DNA markers paternity was assigned to pups derived during the group housing period. In contrast to our initial hypothesis, dominant and subordinate males sired a similar percentage of pups. Taken together, host social status may not predict reproductive success or susceptibility to hantaviruses in rodent reservoir populations.