Lack of association between the interleukin‐1 gene complex and schizophrenia in a Japanese population
Lack of association between the interleukin‐1 gene complex and schizophrenia in a Japanese population
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DOI：
10.1111/j.1440-1819.2007.01671.x
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发表时间：
2007-08
影响因子：
11.9
通讯作者：
Yuichiro Watanabe;A. Nunokawa;N. Kaneko;T. Muratake;Masataka Koizumi;T. Someya
中科院分区：
文献类型：
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作者：
Yuichiro Watanabe;A. Nunokawa;N. Kaneko;T. Muratake;Masataka Koizumi;T. Someya
白细胞介素-1（IL-1）是一种炎性细胞因子，在大脑中发挥神经退行性作用。一些研究表明，IL 1可能参与精神分裂症的发病机制。最近的遗传学研究表明，IL-1基因复合体（IL，1 α，IL-1，β和IL-1受体拮抗剂）与精神分裂症有关，尽管也有相互矛盾的发现。为了评估IL 1基因复合体是否与精神分裂症易感性有关，作者对日本受试者的9种多态性进行了病例对照关联研究（416例精神分裂症患者和440例对照受试者）。作者使用单标记或单体型分析发现IL 1基因复合物多态性与精神分裂症之间没有关联。本研究的结果表明，IL-1基因复合体并没有发挥重要作用，在赋予精神分裂症的易感性在日本人口。
Abstract Interleukin‐1 (IL1) is an inflammatory cytokine and exerts neurodegenerative effects in the brain. Several studies have indicated that IL1 is likely to be involved in the pathogenesis of schizophrenia. Recent genetic studies have revealed that the IL1 gene complex (IL,1 alpha, IL1, beta and IL1 receptor antagonist) was associated with schizophrenia, although contradictory findings have also been reported. To assess whether the IL1 gene complex was implicated in vulnerability to schizophrenia, the authors conducted a case‐control association study (416 patients with schizophrenia and 440 control subjects) for nine polymorphisms in Japanese subjects. The authors found no association between the IL1 gene complex polymorphisms and schizophrenia using either single‐marker or haplotype analyses. The results of the present study suggest that the IL1 gene complex does not play a major role in conferring susceptibility to schizophrenia in the Japanese population.