APNEA AND SUDDEN UNEXPECTED DEATH IN INFANTS WITH ACHONDROPLASIA
APNEA AND SUDDEN UNEXPECTED DEATH IN INFANTS WITH ACHONDROPLASIA
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DOI：
10.1016/s0022-3476(84)81092-6
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发表时间：
1984-01-01
影响因子：
5.1
通讯作者：
LEBOVITZ, R
中科院分区：
文献类型：
--
作者：
PAULI, RM;SCOTT, CI;LEBOVITZ, R
通过非系统的回顾性病例收集，发现13例软骨发育不全和突然意外死亡或不明原因呼吸暂停的婴儿。大多数人最初被认为死于婴儿猝死综合症。然而，历史和病理结果表明，这些婴儿中的许多人有呼吸暂停和突发意外死亡继发于急性或慢性压迫下脑干或颈脊髓。患有软骨发育不全的婴儿在1个月至1岁之间的死亡风险明显增加。考虑到这些以前未认识到的风险，适当的干预可能包括颈椎约束、多导睡眠图评估和呼吸暂停监测。
Thirteen infants with achondroplasia and sudden unexpected death or unexplained apnea were discovered through nonsystematic retrospective case collection. Most were initially thought to have died from sudden infant death syndrome. However, historical and pathologic findings suggest that many of these infants had apnea and sudden unexpected death secondary to acute or chronic compression of the lower brainstem or cervical spinal cord. Infants with achondroplasia evidently are at considerably increased risk for such deaths between 1 month and 1 year of age. Appropriate intervention, given these previously unrecognized risks, may include cervical restraint, polysomnographic evaluation, and apnea monitoring.