Factor analysis of gated cardiac blood‐pool data: application to patients with congenital heart disease
Factor analysis of gated cardiac blood‐pool data: application to patients with congenital heart disease
复制标题
门控心脏血池数据的因子分析：在先天性心脏病患者中的应用
DOI：
10.1097/00006231-199110000-00005
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发表时间：
1991
影响因子：
1.5
通讯作者：
K. Takeda
中科院分区：
文献类型：
--
作者：
T. Ito;H. Maeda;K. Takeda
应用门控平衡法核素心室造影的因子分析法评价左向右分流先天性心脏病（CHD）患者的心室排空功能。在38例室间隔缺损患者中的36例（95%）和21例房间隔缺损患者中的20例（95%）伴小L-R分流（肺动脉-体循环血流量，Qp/Qs ≤ 2.5）以及所有动脉导管未闭患者中，提取了两个有意义的心脏因子，分别对应于心室（心室因子）和心房加大血管（心房因子）。而9例室间隔缺损伴大左-右分流（Qp/Qs > 2.5）的患者，其右心室和左心室（RV和LV）均测得两个不同的心室因子。右心室射血相较左心室射血相延迟，且与Qp/Qs值相关（r = 0.82，P < 0.01）。在10例有较大左-右分流（Qp/Qs > 2.5）的ASD患者中，8例（80%）的RV可由位于间隔区和游离壁区的两种不同心室因子描述。左心室以与右心室间隔区相同的因子提取。本研究表明，因子分析的能力，在CDH的病理生理研究与L-R分流。
Ventricular emptying was evaluated in patients with congenital heart disease (CHD) with left-to-right (L-R) shunt by factor analysis of gated equilibrium radionuclide angiography. In 36 (95%) of 38 ventricular septal defect patients and 20 (95%) of 21 atrial septal defect patients with small L-R shunt (pulmonary to systemic blood flow, Qp/Qs ≤ 2.5), as well as all patent ductus arteriosus patients, two significant cardiac factors corresponding to the ventricles (ventricular factor) and the atria plus large vessels (atrial factor) were extracted. However, in all of nine ventricular septal defect patients with large L-R shunt (Qp/Qs > 2.5), two different ventricular factors were determined which corresponded to the right and left ventricles (RV and LV). The RV factor showed a delay of ejection phase compared with the LV factor, and the delay was correlated with the value of Qp/Qs (r = 0.82, P < 0.01). In eight (80%) of 10 ASD patients with large L-R shunt (Qp/Qs > 2.5), RV was described by the two different ventricular factors located in the septal and free-wall regions. The LV was extracted in the same factor as that located in the septal region of RV. This study demonstrates the capability of factor analysis in the pathophysiological investigation of CDH with L-R shunt.