Plasma proANP decreases after meal intake.
Plasma proANP decreases after meal intake.
复制标题
进餐后血浆 proANP 降低。
作者：
J. Goetze
致编辑：
心脏利钠肽及其分子前体片段是充血性心力衰竭和左心室功能不全的敏感血浆标志物。大多数关于其作为心脏病标志物的价值的研究也讨论了年龄和性别的影响，其中年龄和女性性别的增加与浓度本身的增加有关，因此建议将其纳入参考区间的建立。生物学变异也与小鼠心脏利钠肽mRNA含量的昼夜节律模式和人类伴随的血浆浓度相关。
新的研究结果表明，利钠肽及其受体参与脂肪和肌肉代谢（1）。这些数据，结合观察到肥胖的人显示较低的血浆浓度比正常体重的个人，表明心脏利钠肽也参与，例如，在代谢综合征，甚至可能在糖尿病。迄今为止，还没有研究测试前心房型利钠肽（proANP）1和前脑型利钠肽（BNP）的血浆浓度是否会受到膳食摄入的影响，膳食摄入是参与葡萄糖代谢的激素的胃肠道输出的标准刺激。因此，
To the Editor:
Cardiac natriuretic peptides and their molecular precursor fragments are sensitive plasma markers of congestive heart failure and left ventricular dysfunction. Most studies on their value as markers in cardiac diseases have also addressed the effects of aging and sex, in which increasing age and female sex are associated with higher concentrations per se and thus are recommended to be included in establishing reference intervals. Biological variation has also been associated with the circadian pattern of cardiac natriuretic peptide mRNA contents in mice and the concomitant plasma concentrations in humans.
New findings have demonstrated that natriuretic peptides and their receptors are involved in fat and muscle metabolism (1). These data, combined with the observation that obese people display lower plasma concentrations than individuals of normal weight, suggest that cardiac natriuretic peptides are also involved, for instance, in the metabolic syndrome and perhaps even in diabetes. No study thus far has tested whether plasma concentrations of pro–atrial-type natriuretic peptide (proANP)1 and pro–brain-type natriuretic peptide (BNP) may be affected by meal intake, a standard stimulus for the gastrointestinal output of hormones involved in glucose metabolism. Therefore, …
影响因子：
15.9
作者：
Bordicchia, Marica;Liu, Dianxin;Collins, Sheila
通讯作者：
Collins, Sheila