Cationic Pillararenes Potently Inhibit Biofilm Formation without Affecting Bacterial Growth and Viability
Cationic Pillararenes Potently Inhibit Biofilm Formation without Affecting Bacterial Growth and Viability
复制标题
DOI：
10.1021/jacs.5b11834
复制
发表时间：
2016-01-27
影响因子：
15
通讯作者：
Cohen, Yoram
中科院分区：
文献类型：
--
作者：
Joseph, Roymon;Naugolny, Alissa;Cohen, Yoram
据估计，高达80%的细菌感染伴随着生物膜的形成。由于生物膜中的细菌对抗生素的敏感性低于浮游状态下的细菌，因此与生物膜相关的感染对健康构成重大威胁，因此迫切需要抗生物膜剂。在这里，我们报道了水溶性阳离子柱芳烃在季铵基团上的不同，有效地抑制了临床重要的革兰氏阳性病原体生物膜的形成。生物膜抑制不是由抗菌活性引起的；因此，这些化合物不应该抑制天然细菌菌群的生长。此外，没有一种阳离子柱芳烃对培养的红细胞造成可检测到的膜损伤或对人体细胞的毒性。结果表明，阳离子柱芳烃具有潜在的用途，在医学应用中，生物膜的形成是一个问题。
It is estimated that up to 80% of bacterial infections are accompanied by biofilm formation. Since bacteria in biofilms are less susceptible to antibiotics than are bacteria in the planktonic state, biofilm-associated infections pose a major health threat, and there is a pressing need for antibiofilm agents. Here we report that water-soluble cationic pillararenes differing in the quaternary ammonium groups efficiently inhibited the formation of biofilms by clinically important Gram-positive pathogens. Biofilm inhibition did not result from antimicrobial activity; thus, the compounds should not inhibit growth of natural bacterial flora. Moreover, none of the cationic pillararenes caused detectable membrane damage to red blood cells or toxicity to human cells in culture. The results indicate that cationic pillararenes have potential for use in medical applications in which biofilm formation is a problem.