CYTOGENETIC STUDIES IN ACUTE PROMYELOCYTIC LEUKEMIA - A SURVEY OF SECONDARY CHROMOSOMAL-ABNORMALITIES
CYTOGENETIC STUDIES IN ACUTE PROMYELOCYTIC LEUKEMIA - A SURVEY OF SECONDARY CHROMOSOMAL-ABNORMALITIES
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DOI：
10.1002/gcc.2870030503
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发表时间：
1991-09-01
影响因子：
3.7
通讯作者：
JONVEAUX, P
中科院分区：
文献类型：
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作者：
BERGER, R;LECONIAT, M;JONVEAUX, P
1977年至1990年间，巴黎圣路易医院血液科对105例急性早幼粒细胞白血病（APL）患者进行了细胞遗传学研究。诊断时检查62例，复发时检查32例，诊断和复发时检查11例。除4例患者外，在所有患者中均观察到典型的t(15;17)（q22;q12）或这种易位的变体。47例诊断时t（15;17）是唯一的变化，21例复发时检查。最常见的继发性改变是8号三体（诊断时为17%）。除t（15;17）外，6例患者在诊断时存在或多或少复杂的染色体异常，17例患者复发。2q35-q37和del（11p）的重排仅在复发时观察到，因此可能是非随机的继发性变化。对19名接受全反式维甲酸治疗的患者进行的细胞遗传学研究并未表明这种治疗会导致染色体异常。
A series of 105 patients with acute promyelocytic leukemia (APL) has been cytogenetically investigated at the Department of Hematology of the Saint-Louis Hospital (Paris) between 1977 and 1990. Sixty-two patients were examined at diagnosis, 32 in relapse, and 11 both at diagnosis and in relapse. The typical t(15;17)(q22;q12) or variants of this translocation were observed in all but four patients. The t(15;17) was the only change in 47 cases at diagnosis and in 21 examined in relapse. The most frequent secondary change was trisomy 8 (17% at diagnosis). More or less complex chromosomal abnormalities in addition to t(15;17) were present in six patients at diagnosis, and in 17 patients in relapse. Rearrangements of 2q35-q37 and del(11p) were observed only in relapse and may thus be nonrandom secondary changes. Cytogenetic studies performed on 19 patients treated with all-trans retinoic acid did not indicate that this treatment induces chromosomal abnormalities.