Thermal injury, intravascular hemolysis, and toxic oxygen products.
Thermal injury, intravascular hemolysis, and toxic oxygen products.
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热损伤、血管内溶血和有毒氧产物。
DOI：
10.1172/jci112620
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Ward,PA
中科院分区：
文献类型：
--
作者：
Hatherill,JR;Till,GO;Bruner,LH;Ward,PA
大鼠皮肤的急性热损伤产生早期的急性血红蛋白血症，其与血液中存在在其表面上不包含可测量量的补体成分的脆性红细胞（RBC）有关。血红蛋白血症和血液中脆性红细胞的出现似乎是补体激活的结果，这导致中性粒细胞产生氧自由基和红细胞损伤。抗氧化剂干预或中性粒细胞或补体耗竭程序能够防止出现脆性红细胞和血红蛋白释放，这在体外和体内都得到了证实。这些数据可能与血红蛋白血症和血红蛋白尿伴随热损伤在人类的并发症。
Acute thermal injury of rat skin produces an early, acute hemoglobinemia that is associated with the presence in blood of osmotically fragile red cells (RBC) that do not contain on their surfaces measurable amounts of complement components. The hemoglobinemia and the appearance in blood of osmotically fragile RBC appear to be the result of complement activation, which leads to oxygen radical production by neutrophils and damage of RBC. This has been demonstrated in vitro as well as in vivo by the ability of antioxidant interventions or neutrophil or complement depletion procedures to prevent the appearance of osmotically fragile RBC and the release of hemoglobin. These data may be relevant to the complications of hemoglobinemia and hemoglobinuria accompanying thermal injury in humans.