Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities
Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities
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DOI：
10.1148/radiol.2431052111
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发表时间：
2007-04-01
期刊：
影响因子：
19.7
通讯作者：
van Buchem, Mark A.
中科院分区：
文献类型：
--
作者：
ten Dam, V. Hester;van den Heuvel, Dominique M. J.;van Buchem, Mark A.
目的：回顾性研究总脑血流量的变化和总的进展之间的关联，脑室周围，和深白色物质hypersignificant.Materials和方法：机构伦理审查委员会批准的前瞻性磁共振（MR）成像研究的协议，所有参与者给予书面知情同意书。参与者还同意将来出于研究目的对其MR数据进行回顾性分析。在普伐他汀在老年高危人群中的前瞻性研究的这个子研究中，研究者在平均间隔33个月（标准差1.4）后对390名无痴呆的老年男性和女性（基线年龄70 - 82岁）进行了重复的MR成像检查。白色高信号用半自动方法定量，总脑血流量用梯度回波相位对比MR成像技术测量。总脑血流量和白色高信号的体积之间的关联进行了分析与logistic regression.Results：基线脑血流量和发病率之间没有关联的总，脑室周围，或深白色物质高信号在基线MR成像。此外，脑血流量的下降与白色高信号总负荷的增加无关。当将白色高信号的总体积分为脑室周围和深部高信号时，总脑血流量每减少50 mL/min，（95%置信区间：1.06，1.66; P = 0.015）发生脑室周围白色物质高信号的风险增加;然而，总脑血流量减少与发生深部白色物质高信号的风险之间没有关联（比值比，1.00 [95%置信区间：0.79，1.25]; P = 0.98）。结论：脑总血流量下降与心室周围体积增加有关，但与深部白色物质高信号无关。
Purpose: To retrospectively investigate the association between changes in total cerebral blood flow and progression of total, periventricular, and deep white matter hyperintensities over time.Materials and Methods: The institutional ethics review board approved the protocol for the prospective magnetic resonance (MR) imaging study, and all participants gave written informed consent. Participants also agreed to future retrospective analysis of their MR data for research purposes. In this substudy of the Prospective Study of Pravastatin in the Elderly at Risk, investigators performed a repeated MR imaging examination after an average interval of 33 months (standard deviation, 1.4) in 390 elderly men and women (ages 70 - 82 years at baseline) without dementia who were at high vascular risk. White matter hyperintensities were quantified with a semiautomatic method, and total cerebral blood flow was measured with a gradient-echo phase-contrast MR imaging technique. The association between total cerebral blood flow and volume of white matter hyperintensities was analyzed with logistic regression.Results: There was no association between baseline cerebral blood flow and prevalence of total, periventricular, or deep white matter hyperintensities at baseline MR imaging. Moreover, decline in cerebral blood flow was not associated with increase in total load of white matter hyperintensities. When the total volume of white matter hyperintensities was separated into periventricular and deep hyperintensities, for every 50 mL/min decrease in total cerebral blood flow there was a 1.32 (95% confidence interval: 1.06, 1.66; P = .015) increase in risk for developing periventricular white matter hyperintensities; there was no association, however, between decrease in total cerebral blood flow and risk of developing deep white matter hyperintensities (odds ratio, 1.00 [95% confidence interval: 0.79, 1.25]; P = .98).Conclusion: Decline in total cerebral blood flow is associated with increase in volume of periventricular but not deep white matter hyperintensities.