Persistent blood glucose reduction upon repeated transcranial electric stimulation in men
Persistent blood glucose reduction upon repeated transcranial electric stimulation in men
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DOI：
10.1016/j.brs.2017.03.011
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发表时间：
2017-07-01
影响因子：
7.7
通讯作者：
Oltmanns, Kerstin M.
中科院分区：
文献类型：
--
作者：
Kistenmacher, Alina;Manneck, Sebastian;Oltmanns, Kerstin M.
背景：人脑的经颅直流电刺激（tDCS）会增加全身葡萄糖耐量。目的/假设：研究这种效应在重复刺激一周后是否持续存在。由于全身葡萄糖摄取与大脑能量稳态有关，因此我们同时测量了脑部高能磷酸盐代谢物。方法：在假手术对照交叉设计中，14 名健康男性接受每日阳极 tDCS 与假手术的测试，为期 8 天。通过循环葡萄糖和胰岛素的浓度来检查全身葡萄糖代谢。通过 (31) 磷磁共振波谱评估脑能量代谢，即三磷酸腺苷 (ATP) 和磷酸肌酸 (PCr) 水平。结果：与第 1 天的假刺激相比，tDCS 后的血糖浓度明显较低。这种效应持续到第 8 天，而血清胰岛素水平持续保持不变。仅在第一天，与假手术相比，经颅刺激增加了 ATP 和 PCr 的平均水平。每日重复刺激后，血糖浓度与 PCr 含量呈负相关。结论：我们的数据证实，经颅直流电刺激 (tDCS) 通过独立于胰岛素的机制降低血糖。这种效果在重复刺激8天后仍然存在，与大脑能量代谢有关。因此，经颅电刺激可能是治疗葡萄糖耐受不良或 2 型糖尿病等全身性疾病的一种有前途的非药物辅助选择，且副作用较低。 (C) 2017 年，爱思唯尔公司出版
Background: Transcranial direct current stimulation (tDCS) of the human brain increases systemic glucose tolerance.Objective/Hypothesis: To investigate whether this effect persists after one week of repeated stimulation. Because systemic glucose uptake relates to brain energy homeostasis, we concomitantly measured cerebral high-energy phosphate metabolites.Methods: In a sham-controlled crossover design, 14 healthy men were tested under daily anodal tDCS vs. sham for 8 days. Systemic glucose metabolism was examined by concentrations of circulating glucose and insulin. Cerebral energy metabolism - i.e. adenosine triphosphate (ATP) and phosphocreatine (PCr) levels - was assessed by (31)phosphorous magnetic resonance spectroscopy.Results: Blood glucose concentrations were distinctly lower upon tDCS compared with sham stimulation on day 1. This effect persisted on day 8, while serum insulin levels remained persistently unchanged. Transcranial stimulation increased mean levels of ATP and PCr compared with sham on day 1 only. Blood glucose concentrations negatively correlated with PCr content after repeated daily stimulation.Conclusions: Our data confirm that tDCS reduces blood glucose through an insulin-independent mechanism. This effect persists after 8 days of repeated stimulation and relates to brain energy metabolism. Therefore, transcranial electric stimulation may be a promising non-pharmacological adjuvant option to treat systemic disorders such as glucose intolerance or type 2 diabetes mellitus with a low side-effect profile. (C) 2017 Published by Elsevier Inc.