Report of the NIH Panel to Define Principles of Therapy of HIV Infection and Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents. Vol. 47/No. RR-5.
Report of the NIH Panel to Define Principles of Therapy of HIV Infection and Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents. Vol. 47/No. RR-5.
复制标题
美国国立卫生研究院 (NIH) 小组的报告，定义了艾滋病毒感染的治疗原则和艾滋病毒感染成人和青少年使用抗逆转录病毒药物的指南。
DOI：
10.1037/e547742006-001
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
J. Kaplan
中科院分区：
文献类型：
--
作者：
M. Feinberg;J. Kaplan
摘要：最近的研究进展大大提高了对人类免疫缺陷病毒（HIV）感染的生物学和获得性免疫缺陷综合征（AIDS）发病机制的认识。随着用于监测感染者体内艾滋病毒复制的敏感工具的出现，可以准确评估疾病进展和死亡的风险，并可以直接确定抗艾滋病毒疗法的疗效。此外，当使用适当的/v时，新可用的有效抗病毒疗法的组合可以实现对可检测水平的HIV复制的长期抑制，并避免HIV产生耐药病毒变体的固有趋势。然而，随着HIV感染的抗逆转录病毒治疗变得越来越有效，它也变得越来越复杂。需要熟悉最新的研究进展，以确保以最有效地改善健康和延长艾滋病毒感染者寿命的方式使用新的治疗方法。这使从业人员和艾滋病毒感染者能够最好地利用迅速积累的有关艾滋病毒疾病发病机制和治疗的新信息，美国国立卫生研究院艾滋病研究办公室赞助了NIH专家组，以确定HIV感染的治疗原则。该专家组被要求确定基本的科学原则，这些原则应用于指导临床中最有效地使用抗逆转录病毒疗法和病毒载量测试。实践基于对最新数据的详细考虑，专家组描绘了解决对治疗HIV感染具有根本重要性的问题的十一项原则。
Abstract : Recent research advances have afforded substantially improved understanding of the biology of human immunodeficiency virus (HIV) infection and the pathogenesis of the acquired immunodeficiency syndrome (AIDS). With the advent of sensitive tools for monitoring HIV replication in in fected persons, the risk of disease progression and death can be assessed accurately and the efficacy of anti-HIV therapies can be determined directly. Furthermore, when used appropriate/v, combinations of newly available, potent antiviral therapies can effect prolonged suppression of detectable levels of HIV replication and circumvent the inherent tendency of HIV to generate drug-resistant viral variants. However, as antiretroviral viral therapy for HIV in fection has become increasingly effective, it has also become increasingly complex. Familiarity with recent research advances is needed to ensure that newly available therapies are used in ways that most effectively improve the health and prolong the fives of HIV infected persons. Th enable practitioners and HIV infected persons to best use rapidly accumulating new information about HIV disease pathogenesis and treatment, the Office of AIDS Research of the National Institutes of Health sponsored the NIH Panel to Define Principles of Therapy of HlV infection This Panel was asked to define essential scientific principles that should be used to guide the most effective use of antiretroviral therapies and viral load testing in clinical practice. Based on detailed consideration of the most current data, the Panel delineated eleven principles that address issues of fundamental importance for the treatment of HlV infection.