LOCATION OF POSTSYNAPTIC INHIBITORY SYNAPSES ON HIPPOCAMPAL PYRAMIDS
LOCATION OF POSTSYNAPTIC INHIBITORY SYNAPSES ON HIPPOCAMPAL PYRAMIDS
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DOI：
10.1152/jn.1964.27.4.592
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发表时间：
1964-01-01
影响因子：
2.5
通讯作者：
ECCLES, JC
中科院分区：
文献类型：
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作者：
ANDERSEN, P;LOYNING, Y;ECCLES, JC
四种不同类型的输入诱发几乎所有的麻醉猫海马锥体细胞大，延长超极化。这些抑制电位类似于其他神经元，因为它们对冲动的产生产生有强大的影响，并且当细胞的Cl含量增加时被逆转为去极化电位。有证据表明，在各种抑制途径内插的interneurons。的主要胞外场电位达到了尖锐的最大阳性的锥体细胞胞体的水平，是抑制性突触后电位[IPSP]的细胞外对应物。结论：锥体细胞胞体上或附近的抑制性突触作用产生IPSP和胞外层电位。有人指出，这个位置给出了最好的战略网站抑制性突触行动。
Four different types of input evoked in virtually all hippocampal pyramidal cells of anaesthetized cats large and prolonged hyperpolarization. These inhibitory potentials resembled those of other neurones in that they had a powerful influence on impulse generation and were reversed to depolarizing potentials when the Cl content of the cell was increased. There was evidence of interpolated interneurones in the various inhibitory pathways. The principal extracellular field potential reached a sharp maximum of positivity at the level of the pyramidal cell somas, and was the extracellular counterpart of the inhibitory postsynaptic potential [IPSP]. It is concluded that inhibitory synaptic action on or close to the pyramidal cell somas generated both the IPSP and the extracellular laminated potential. It is pointed out that this location gives the best strategic site for inhibitory synaptic action.