Depression, Anxiety, and Stress in Young Adults with Phenylketonuria: Associations with Biochemistry
Depression, Anxiety, and Stress in Young Adults with Phenylketonuria: Associations with Biochemistry
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DOI：
10.1097/dbp.0000000000000072
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发表时间：
2014-07-01
影响因子：
2.4
通讯作者：
McGill, Jim
中科院分区：
文献类型：
--
作者：
Clacy, Amanda;Sharman, Rachael;McGill, Jim
Objective: Increasing concurrent phenylalanine to "off-diet" levels in adults with phenylketonuria (PKU) has been shown to lead to mood disturbances. However, the impact of controlled phenylalanine exposure across the developmental life span and mood stability remains questionable. The aim of this study was to investigate correlations between lifetime and concurrent phenylalanine (Phe) and tyrosine (Tyr) with levels of depression, anxiety, and stress in young adults maintaining a continuously treated diet for PKU. Method: Eight young adults (6 females, 2 males) aged 15 to 25 years (mean = 19.37, SD = 3.62) recruited through the Royal Children's Hospital Brisbane, with early and continuously treated PKU completed the Depression Anxiety Stress Scale, which was correlated with lifetime and concurrent measures of Phe, Tyr, and Phe-Tyr ratios. Results: There was a strong significant correlation between lifetime Phe and levels of anxiety and stress (p
