Use of cryopreserved bone marrow in allogeneic bone marrow transplantation.
Use of cryopreserved bone marrow in allogeneic bone marrow transplantation.
复制标题
冷冻保存的骨髓在同种异体骨髓移植中的应用。
DOI：
--
复制
发表时间：
1995
影响因子：
4.8
通讯作者：
A. Zander
中科院分区：
文献类型：
--
作者：
M. Stockschläder;W. Krüger;G. Kroschke;W. Zeller;M. Hoffknecht;C. Löliger;H. Kabisch;A. Zander
使用冷冻保存的供体骨髓可以通过提供骨髓捐献的固定时间的独立性来促进异基因骨髓移植（BMT）的时间安排。然而，必须考虑到冷冻保存对造血干细胞的潜在损害风险，导致移植物植入延迟或移植失败。为了解决这些问题，我们分析了19例使用冷冻供体骨髓进行的匹配相关BMT（1992-94）的结果，并与19例接受新鲜供体骨髓的相关BMT（1990-93）（对照组）进行了比较。接受冻存骨髓的患者的植入时间与对照组没有差异（ANC > 0.2 x 10（9）/l 15.5 +/- 3.8天vs 15.8 +/- 5.0天; ANC > 0.5 x 10（9）/l 17.3 +/- 4.1天vs 17.9 +/- 5.0天）。与接受新鲜骨髓的患者相比，我们没有发现先前描述的接受冷冻骨髓的患者急性GVHD发生率较低的趋势（急性GVHD >或= II 78 vs 64%）。此外，两组在慢性GVHD的发生率（55 vs 38%）或第100天生存率（74 vs 68%）方面没有差异。我们的结论是，在同种异体BMT中，冷冻保存的骨髓细胞可以安全地使用，而不会危及或延长植入时间。
Use of cryopreserved donor bone marrow may facilitate scheduling of allogeneic bone marrow transplantation (BMT) by affording independence of a fixed time for bone marrow donation. The potential risk of damage to hematopoietic stem cells by cryopreservation resulting in delayed engraftment or graft failure has to be taken into account, however. To address these issues, the outcome of 19 matched related BMT (1992-94) performed with cryopreserved donor bone marrow was analyzed and compared with 19 related BMT (1990-93) receiving fresh donor bone marrow (control group). Time to engraftment of patients receiving cryopreserved bone marrow was not different from the control group (ANC > 0.2 x 10(9)/l 15.5 +/- 3.8 days vs 15.8 +/- 5.0 days; ANC > 0.5 x 10(9)/l 17.3 +/- 4.1 days vs 17.9 +/- 5.0 days, respectively). We did not find the previously described trend toward a lower incidence of acute GVHD in patients receiving cryopreserved bone marrow compared with patients receiving fresh bone marrow (acute GVHD > or = II 78 vs 64%). Furthermore, the two groups did not differ in the incidence of chronic GVHD (55 vs 38%) or day 100 survival (74 vs 68%). We conclude that in allogeneic BMT cryopreserved bone marrow cells can be safely used without jeopardising or prolonging time to engraftment.