Growth Factors and Cell Homing in Dental Tissue Regeneration.
Growth Factors and Cell Homing in Dental Tissue Regeneration.
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DOI：
10.1007/s40496-018-0194-y
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发表时间：
2018-12-01
影响因子：
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通讯作者：
Shimizu, Emi
中科院分区：
文献类型：
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作者：
Duncan, Henry F;Kobayashi, Yoshifumi;Shimizu, Emi
综述目的：总结目前关于生长因子 (GF) 在牙髓细胞归巢中的作用和治疗潜力的观点。最新发现：细胞归巢/再生技术旨在利用内源细胞再生牙本质和牙髓。临床上，再生术成功地在根尖开放的坏死恒牙中创造了新的有生命的组织；然而，没有证据表明有新的成牙本质细胞、牙髓组织或可预测的根长延长。尽管反应是修复性的而不是再生性的，但改进这些基于生物学的策略的令人兴奋的机会仍然存在：（1）使用冲洗剂和牙科材料有效隔离牙本质基质成分（DMC）（2）设计下一代释放 GF 的支架材料以及（3）利用其他 GF 来源，例如细胞和富含血浆的血浆和富含血浆的血浆。 纤维蛋白。总结：GF 可以促进修复性牙本质发生和牙髓样组织形成。 GF功能化支架的未来开发和临床批准是当务之急；然而，当前的重点应该是利用 DMC 并针对干细胞和 GF 的相互作用。
PURPOSE OF REVIEW: To summarize current views on the role and therapeutic potential of growth factors (GFs) within endodontic cell homing.RECENT FINDINGS: Cell homing/revitalization techniques aim to regenerate dentin and pulp using endogenous cells. Clinically, revitalization has successfully created new vital tissue in necrotic permanent teeth with an open apex; however, there is no evidence of new odontoblasts, pulp tissue, or predictable extension in root length. Although the response is reparative rather than regenerative, exciting opportunities to improve these biologically-based strategies remain by (1) efficiently sequestering dentin-matrix-components (DMCs) using irrigants and dental materials (2) designing next-generation GF-releasing scaffold materials and (3) utilizing other sources of GF such as cells and plasma-rich plasma and plasma-rich fibrin.SUMMARY: GFs can promote reparative-dentinogenesis and pulp-like tissue formation. The future development and clinical approval of GF-functionalized-scaffolds is a priority; however, current focus should be to harness DMCs and target the interaction of stem cells and GFs.