Oral Fluoride Reservoirs and the Prevention of Dental Caries
Oral Fluoride Reservoirs and the Prevention of Dental Caries
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DOI：
10.1159/000325166
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发表时间：
2011-01-01
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影响因子：
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通讯作者：
Vogel, Gerald Lee
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作者：
Vogel, Gerald Lee
目前用于增加氟化物（F）试剂的抗龋齿作用的模型强调在口腔流体中保持F的防龋浓度的重要性。口腔液中的氟浓度是通过从牙齿、口腔粘膜上的生物可利用储库释放这种离子来维持的，最重要的是，因为它与龋齿过程有关-牙菌斑。口腔氟储库似乎有两种类型：（1）矿物储库，特别是氟化钙或磷酸盐污染的“氟化钙样”沉积物;（2）生物储库，特别是（关于牙菌斑）通过氟化钙键与细菌或细菌碎片结合的氟。所有这些储库都由钙介导的事实意味着它们的形成受到口腔液中低浓度钙的限制。通过使用新的程序，克服了这一限制，这些F水库的形成后，局部F应用可以大大增加。虽然这些增加与唾液和菌斑液F的实质性增加有关，因此潜在的防龋作用增加，但尚不清楚这些变化是否与这些储库量的增加或形成的F沉积物类型的变化有关。已经开发了新的技术，用于识别和量化这些存款，这应该证明是有用的开发剂，提高口腔氟水库的形成与最佳的F释放特性。这样的研究提供了降低局部药剂的F含量同时增加其防龋效果的前景。版权所有（C）2011 S. Karger AG，巴塞尔
Current models for increasing the anti-caries effects of fluoride (F) agents emphasize the importance of maintaining a cariostatic concentration of F in oral fluids. The concentration of F in oral fluids is maintained by the release of this ion from bioavailable reservoirs on the teeth, oral mucosa and - most importantly, because of its association with the caries process - dental plaque. Oral F reservoirs appear to be of two types: (1) mineral reservoirs, in particular calcium fluoride or phosphate contaminated 'calcium-fluoride-like' deposits; (2) biological reservoirs, in particular (with regard to dental plaque) F held to bacteria or bacterial fragments via calcium-fluoride bonds. The fact that all these reservoirs are mediated by calcium implies that their formation is limited by the low concentration of calcium in oral fluids. By using novel procedures which overcome this limitation, the formation of these F reservoirs after topical F application can be greatly increased. Although these increases are associated with substantive increases in salivary and plaque fluid F, and hence a potential increase in cariostatic effect, it is unclear if such changes are related to the increases in the amount of these reservoirs, or changes in the types of F deposits formed. New techniques have been developed for identifying and quantifying these deposits which should prove useful in developing agents that enhance formation of oral F reservoirs with optimum F release characteristics. Such research offers the prospect of decreasing the F content of topical agents while simultaneously increasing their cariostatic effect. Copyright (C) 2011 S. Karger AG, Basel