An update of cancer mortality among the French cohort of uranium miners: Extended follow-up and new source of data for causes of death
An update of cancer mortality among the French cohort of uranium miners: Extended follow-up and new source of data for causes of death
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DOI：
10.1023/b:ejep.0000017824.38966.01
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发表时间：
2004-02-01
影响因子：
13.6
通讯作者：
Quesne, B
中科院分区：
文献类型：
--
作者：
Laurier, D;Tirmarche, M;Quesne, B
对法国铀矿工人的后续工作已延长至1994年，并使用了一种新的死亡原因资料来源。本文介绍了关于队列中死亡风险的新结果，并分析了方法变化对这些结果的影响。与之前的分析相比，随访时间的延长导致统计效力大幅增加（人年增加25%，死亡人数增加74%）。使用国家死亡率数据库作为死亡原因的主要来源，可以减少标准化死亡率（SMR）计算中的潜在偏差。因此，第一次分析中提出的喉癌死亡风险过高的说法并未得到证实。分析表明，法国铀矿工人存在肺癌死亡的超额风险（85例观察到的死亡，SMR = 1.9, 95%置信区间CI: 1.5 - 2.3），并且这种风险随着氡的累积暴露而增加（每100个工作水平月的超额相对风险= 0.6,95%置信区间CI: 0.1 - 1.2）。这些结果证实，长期暴露于相对低水平氡的人群存在死于肺癌的风险。
The follow-up of the French cohort of uranium miners has been extended to 1994, and a new source of information for causes of death has been used. The paper presents the new results regarding the risk of death among the cohort, and analyses the impact of the methodological changes on these results. The extension of the follow-up results in a substantial increase in statistical power compared with previous analysis (+25% for person-years and +74% for the number of deaths). The use of the National Mortality Database as the principal source for causes of death allows to reduce the potential bias in the calculation of standardized mortality ratios (SMR). As a consequence, an excess risk of deaths from laryngeal cancer, suggested in the first analysis, is not con firmed. The analysis shows the existence of an excess risk of deaths from lung cancer among French uranium miners ( 85 observed deaths, SMR = 1.9, 95% confidence interval CI: 1.5 - 2.3), and an increase of this risk with cumulative exposure to radon ( excess relative risk per 100 working level month = 0.6, 95% CI: 0.1 - 1.2). These results confirm the existence of a risk of death from lung cancer in a population chronically exposed to relatively low levels of radon.