Thermal and photochemical switching of conformation of poly(ethylene glycol)-substituted cyclodextrin with an azobenzene group at the chain end
Thermal and photochemical switching of conformation of poly(ethylene glycol)-substituted cyclodextrin with an azobenzene group at the chain end
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DOI：
10.1021/ja071717q
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发表时间：
2007-05-23
影响因子：
15
通讯作者：
Harada, Akira
中科院分区：
文献类型：
--
作者：
Inoue, Youhei;Kuad, Paul;Harada, Akira
合成了在聚乙二醇（PEG）链末端具有偶氮苯基的聚乙二醇取代的环糊精（6-Az-PEG 600-HyCiO-beta-CD）。6-Az-PEG 600-HyCiO-beta-CD在水溶液中的构象可以通过热和光化学方法控制。在低浓度下，6-trans-Az-PEG 600-HyCiO-beta-CD形成不同类型的自包合物或根据温度以脱螺纹形式存在，而在高浓度下，形成分子间复合物。此外，紫外光照射诱导的构象变化的自包合复合物中的CD腔包括偶氮苯部分，无论浓度。
Poly(ethylene glycol) (PEG)-substituted cyclodextrin (CD) with an azobenzene group at the terminal of the PEG chain (6-Az-PEG600-HyCiO-beta-CD) was synthesized. The conformation of 6-Az-PEG600-HyCiO-beta-CD in aqueous solution could be controlled thermally and photochemically. At low concentration, 6-trans-Az-PEG600-HyCiO-beta-CD formed different types of self-inclusion complexes or existed in a dethreading form depending on the temperature, while at high concentration, an intermolecular complex was formed. Moreover, UV-light irradiation induced a conformational change to a self-inclusion complex where the CD cavity included the azobenzene part regardless of the concentration.