Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse:: multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS
Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse:: multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS
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DOI：
10.1016/j.gene.2003.08.007
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发表时间：
2003-12-04
期刊：
影响因子：
3.5
通讯作者：
Yankovsky, N
中科院分区：
文献类型：
--
作者：
Baranova, A;Hammarsund, M;Yankovsky, N
在本研究中，我们描述了人类和小鼠RFP 2基因结构，在两个物种中具有不同5'UTR的多种RFP 2 mRNA亚型和人类特异性反义转录本RFP 2 OS。由于人RFP 2 5' UTR在小鼠中不保守，这些发现可能表明RFP 2在两个物种中的不同调节。预测的人类和小鼠RFP 2蛋白显示含有三重RING指-B-盒-卷曲-螺旋结构域（RBCC），也称为TRIM结构域，因此属于经常参与发育和致瘤过程的RING指蛋白的亚组。由于染色体区域13q14.3的纯合缺失在许多恶性肿瘤中被发现，包括慢性淋巴细胞白血病（CLL）和多发性骨髓瘤（MM），我们认为RFP 2可能参与肿瘤的发展。本研究为评价RFP 2在恶性转化和其他生物学过程中的作用提供了必要的信息。(C)2003 Elsevier B. V.保留所有权利。
In the present study, we describe the human and mouse RFP2 gene structure, multiple RFP2 mRNA isoforms in the two species that have different 5' UTRs and a human-specific antisense transcript RFP2OS. Since the human RFP2 5' UTR is not conserved in mouse, these findings might indicate a different regulation of RFP2 in the two species. The predicted human and mouse RFP2 proteins are shown to contain a tripartite RING finger-B-box-coiled-coil domain (RBCC), also known as a TRIM domain, and therefore belong to a subgroup of RING finger proteins that are often involved in developmental and tumorigenic processes. Because homozygous deletions of chromosomal region 13q14.3 are found in a number of malignancies, including chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), we suggest that RFP2 might be involved in tumor development. This study provides necessary information for evaluation of the role of RFP2 in malignant transformation and other biological processes. (C) 2003 Elsevier B.V. All rights reserved.