Incidence of and risk factors for pancreatic cancer in chronic pancreatitis: A cohort of 1656 patients
Incidence of and risk factors for pancreatic cancer in chronic pancreatitis: A cohort of 1656 patients
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DOI：
10.1016/j.dld.2017.07.001
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发表时间：
2017-11-01
影响因子：
4.5
通讯作者：
Hu, Liang-Hao
中科院分区：
文献类型：
--
作者：
Hao, Lu;Zeng, Xiang-Peng;Hu, Liang-Hao
背景：慢性胰腺炎患者罹患胰腺癌的风险可能增加。目的：本研究旨在了解慢性胰腺炎患者胰腺癌的发病率及危险因素。方法：纳入2000年1月至2013年12月本中心收治的慢性胰腺炎患者。计算胰腺癌的累积发生率和生存率。根据中国一般人群胰腺癌发病率计算标准化发病率。确定了胰腺癌的危险因素。结果：在总共 1656 名患者中，中位随访时间为 8.0 年。 21 名患者（1.3%）检出胰腺癌。胰腺癌的预期病例数为 1.039，标准化发病率为 20.22。吸烟史 > 60 包/年的患者的标准化发病率要高得多 (145.82)。确定了胰腺癌的两个危险因素：慢性胰腺炎发病年龄（风险比，1.05）和> 60包年吸烟史（风险比，11.83）。结论：与一般人群相比，慢性胰腺炎患者患胰腺癌的风险明显增加，特别是发病年龄较大且有> 60包年吸烟史的患者。建议对高危人群进行密切随访。 (C) 2017 Editrice Gastroenterologica Italiana S.r.l.由爱思唯尔有限公司出版。保留所有权利。
Background: Risk of pancreatic cancer may increase in chronic pancreatitis patients.Aims: This study aimed to identify the incidence of and risk factors for pancreatic cancer in chronic pancreatitis patients.Methods: Chronic pancreatitis patients admitted to our center from January 2000 to December 2013 were enrolled. Cumulative rates of pancreatic cancer and survival rates were calculated. The standardized incidence ratio was calculated based on the pancreatic cancer incidence in general population of China. Risk factors for pancreatic cancer were identified.Results: In a total of 1656 patients, the median follow-up duration was 8.0 years. Pancreatic cancer was detected in 21 patients (1.3%). The expected number of cases of pancreatic cancer was 1.039, yielding a standardized incidence ratio of 20.22. The standardized incidence ratios for patients with a >60 pack-year smoking history were much higher (145.82). Two risk factors for pancreatic cancer were identified: age at the onset of chronic pancreatitis (hazard ratio, 1.05) and a >60 pack-year smoking history (hazard ratio, 11.83).Conclusion: The risk of pancreatic cancer is markedly increased in chronic pancreatitis patients compared with the general population, especially in patients with an older age at onset and a >60 pack-year smoking history. The high-risk populations were suggested to be followed up closely. (C) 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.