Task-guided selection of the dual neural pathways for reading
Task-guided selection of the dual neural pathways for reading
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DOI：
10.1016/j.neuron.2006.09.030
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发表时间：
2006-11-09
期刊：
影响因子：
16.2
通讯作者：
Ugawa, Yoshikazu
中科院分区：
文献类型：
--
作者：
Nakamura, Kimihiro;Hara, Nobuko;Ugawa, Yoshikazu
人们知道，对单词的视觉感知会自动激活对口语形式的听觉表征。我们使用经颅磁刺激（TMS）和隐藏启动范式研究了这种语音激活的神经机制。刺激部位（左颞上回[L-STG]和顶叶下叶[L-IPL]）、目标模态（视觉和听觉）和任务（发音和词汇决策）是独立操作的。在跨模态和内模态条件下，发音过程中的重复启动在刺激L-IPL时被消除，而在刺激L-STG时没有被消除，而词汇决策过程中的启动在刺激L-STG时被消除，而在刺激L-IPL时没有。观察到的双重分离表明，有意识的任务指令调节刺激驱动的颞外侧皮层词汇语音激活和顶叶下皮层口语产生的激活，从而使不同的神经网络产生适当的行为反应。
The visual perception of words is known to activate the auditory representation of their spoken forms automatically. We examined the neural mechanism for this phonological activation using transcranial magnetic stimulation (TMS) with a masked priming paradigm. The stimulation sites (left superior temporal gyrus [L-STG] and inferior parietal lobe [L-IPL]), modality of targets (visual and auditory), and task (pronunciation and lexical decision) were manipulated independently. For both within- and cross-modal conditions, the repetition priming during pronunciation was eliminated when TMS was applied to the L-IPL, but not when applied to the L-STG, whereas the priming during lexical decision was eliminated when the L-STG, but not the L-IPL, was stimulated. The observed double dissociation suggests that the conscious task instruction modulates the stimulus-driven activation of the lateral temporal cortex for lexico-phonological activation and the inferior parietal cortex for spoken word production, and thereby engages a different neural network for generating the appropriate behavioral response.