Obese Nondiabetic Pregnancies and High Maternal Glycated Hemoglobin at Delivery as an Indicator of Offspring and Maternal Postpartum Risks: The Prospective PEACHES Mother-Child Cohort
Obese Nondiabetic Pregnancies and High Maternal Glycated Hemoglobin at Delivery as an Indicator of Offspring and Maternal Postpartum Risks: The Prospective PEACHES Mother-Child Cohort
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DOI：
10.1373/clinchem.2015.242206
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发表时间：
2015-11-01
影响因子：
9.3
通讯作者：
von Kries, Ruediger
中科院分区：
文献类型：
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作者：
Ensenauer, Regina;Brandlhuber, Lena;von Kries, Ruediger
背景：我们调查了妊娠期糖尿病（GDM）阴性的肥胖孕妇是否仍会出现血糖异常，如分娩时高血糖化血红蛋白（Hb A(1c)）所示，以及这是否会影响后代和母亲的长期结局。方法：对462对儿童肥胖风险增加的前瞻性规划-早期筛查（PEACHES）队列研究的数据进行分析。根据国际糖尿病和妊娠研究小组协会的标准，在接受GDM检测后，对885名肥胖和体重正常的孕妇进行了前瞻性研究，其中462名GDM阴性的母亲及其后代进行了调查。我们评估了分娩时母亲血红蛋白A（1c）与大胎龄（LGA）出生体重、脐带血c肽以及产后2.9年（中位数）肥胖母亲的糖代谢和炎症生物标志物的关系（n = 42）。结果：gdm阴性正常体重妇女（n = 155）的累积分布分析显示，12%的妇女分娩时Hb A(1c), bb0 = 5.7%（高Hb A(1c)）。在gdm阴性的肥胖女性（n = 307）中，31.9% （95% CI, 26.7%-37.4%）达到或超过了这个临界值。在肥胖的gdm阴性女性中，Hb A(1c) >= 5.7% （n = 98）
BACKGROUND: We investigated whether obese pregnant women negative for gestational diabetes (GDM) still experience dysglycemia, as indicated by high glycated hemoglobin (Hb A(1c)) at delivery, and whether this impacts offspring and long-term maternal outcomes.METHODS: Data of 462 mother-child pairs of our prospective Programming of Enhanced Adiposity Risk in Childhood - Early Screening (PEACHES) cohort study were analyzed. Of 885 obese and normal-weight pregnancies prospectively enrolled after GDM testing according to the International Association of Diabetes and Pregnancy Study Groups criteria, 462 GDM-negative mothers and their offspring were investigated. We assessed associations of maternal Hb A(1c) at delivery with large-for-gestational-age (LGA) birth weights, cordblood C-peptide, and biomarkers of glucose metabolism and inflammation in obese mothers followed for 2.9 years (median) postpartum (n = 42).RESULTS: Cumulative distribution analysis in GDM-negative normal-weight women (n = 155) revealed that 12% had Hb A(1c) >= 5.7% at delivery (high Hb A(1c)). Among obese GDM-negative women (n = 307), 31.9% (95% CI, 26.7%-37.4%) equaled or exceeded this cutoff. In obese GDM-negative women with Hb A(1c) >= 5.7% (n = 98) vs