Are interatrial band myocytes maximally hypertrophied in normal canine hearts?
Are interatrial band myocytes maximally hypertrophied in normal canine hearts?
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正常犬心脏中心房带肌细胞是否最大程度肥大？
DOI：
10.1152/ajpheart.1998.275.4.h1225
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
GreenfieldJr,JC
中科院分区：
文献类型：
--
作者：
Dolber,PC;Bauman,RP;Rembert,JC;GreenfieldJr,JC
在犬右心房肥大中，右心房肌细胞的横截面积（Axs）增加，而更宽的心房间带肌细胞的Axs则没有增加。在目前的研究中，肌细胞重建显示右心房肥大时右心房肌细胞长度与Axn成比例增加。另一方面，正常和右心房肥大犬的平均房间隔带肌细胞长度与平均Axs大致成反比，正如预期的那样，如果房间隔带肌细胞体积恒定。绘图意味着Axsvs。单个心房间带肌细胞的肌细胞长度显示其边界限定最大体积曲线的分布;许多肌细胞正好在该曲线下方。单核肌细胞（通常是二倍体）受到65，000 μ m3曲线的限制，许多双核肌细胞（通常是四倍体）超过了该曲线;因此，肌细胞倍性限制了肌细胞体积。然而，由于许多单核和双核肌细胞的体积较低，它们不能肥大归因于达到其倍性可能的最大体积。
In canine right atrial hypertrophy, the cross-sectional area (Axs) of right atrial myocytes increases, whereas theAxsof the broader interatrial band myocytes does not. In the current study, myocyte reconstructions showed that right atrial myocyte length increased in proportion toAxsin right atrial hypertrophy. On the other hand, mean interatrial band myocyte length in both normal and right atrial hypertrophy dogs was roughly inversely proportional to meanAxs, as expected if interatrial band myocyte volume was constant. Plotting meanAxsvs. myocyte length for individual interatrial band myocytes revealed a distribution whose border defined a maximal volume curve; many myocytes were well beneath that curve. Mononuclear myocytes (generally diploid) were limited by a 65,000-μm3curve, which many binuclear myocytes (generally tetraploid) surpassed; myocyte ploidy thus constrained myocyte volume. However, because many mononuclear and binuclear myocytes had lower volumes, their failure to hypertrophy cannot be attributed to attainment of the maximal volume possible for their ploidy.