Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARγ gene and colorectal cancer risk in Japanese
Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARγ gene and colorectal cancer risk in Japanese
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DOI：
10.1111/j.1349-7006.2006.00314.x
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发表时间：
2006-11-01
期刊：
影响因子：
5.7
通讯作者：
Tajima, Kazuo
中科院分区：
文献类型：
--
作者：
Kuriki, Kiyonori;Hirose, Kaoru;Tajima, Kazuo
过氧化物酶体增殖物激活受体γ (PPAR γ)基因在能量稳态中起重要作用。为了研究食物和脂肪酸的摄入与结肠直肠癌的Pro12Ala和C161T （His447His）多态性之间的相互作用，我们在日本进行了两项病例对照研究。在研究1中，有128例结直肠癌病例和238例非癌症对照，在研究2中有257例病例和771例（年龄和性别匹配）非癌症对照。在研究1中，对食物和营养素消耗的评估是通过一份包含九个项目的调查问卷进行的，而在研究2中，对消费的评估是根据一份更详细的半定量食物频率调查问卷进行的。食物和脂肪酸的摄取量被分为低、中、高三组。Ala等位基因的总频率< 4%，Pro/Pro + C/C和Pro/Pro + (C/T + T/T)基因型的频率分别为70 ~ 73%和20 ~ 26%。研究1中，与低肉类摄取量和Pro/Pro + C/C基因型的受试者相比，高肉类摄取量和相同基因型的受试者风险增加更强[OR， 2.88；95% ci, 1.14-7.30；但在研究2中，Pro/Pro + (C/T + T/T)基因型（P趋势= 0.05）与加工肉制品消费量呈正相关（P趋势= 0.05）。同样，在Pro/Pro和Pro/Pro + C/C基因型的人群中，高饱和脂肪酸和牛奶的摄入似乎分别给风险带来了边际增加和更大的风险降低（OR， 1.35和0.65;95% CI, 0.93-1.96和0.43-1.00；趋势P = 0.10和0.06）。在Ala等位基因频率极低的日本人中，PPAR γ基因多态性与肉类、加工肉类、牛奶和饱和脂肪酸的膳食摄入量之间的关系，需要进一步的大规模研究来确定结直肠癌的风险。
The peroxisome proliferator-activated receptor gamma (PPAR gamma) gene plays important roles in energy homeostasis. To examine interactions between consumption of foods and fatty acids and the Pro12Ala and C161T (His447His) polymorphisms for colorectal cancer, we performed two case-control studies in Japanese. In study 1, there were 128 colorectal cancer cases and 238 non-cancer controls, and in study 2 there were 257 cases and 771 (age- and sex-matched) non-cancer controls. Assessment of food and nutrients consumption in study 1 was via a nine-item questionnaire, while in study 2 assessment of consumption was according to a more detailed semiquantitative food frequency questionnaire. Consumption of foods and fatty acids was divided into low, moderate and high groups. The overall frequency of the Ala allele was < 4%, and the frequencies of the Pro/Pro + C/C and Pro/Pro + (C/T + T/T) genotypes were 70-73% and 20-26%, respectively. Compared with subjects with low meat intake and the Pro/Pro + C/C genotype, those with high meat consumption and the same genotype had a stronger increased risk in study 1 [OR, 2.88; 95% CI, 1.14-7.30; P for trend = 0.02], but a positive association with processed meat consumption was greatest in those with the Pro/Pro + (C/T + T/T) genotype (P for trend = 0.05) in study 2. Likewise, high consumption of saturated fatty acids and milk appeared to confer marginal increased risk and stronger decreased risk, respectively, in those with the Pro/Pro and Pro/Pro + C/C genotypes (OR, 1.35 and 0.65; 95% CI, 0.93-1.96 and 0.43-1.00; P for trend = 0.10 and 0.06). Further large-scale studies are needed to determine colorectal cancer risk according to relationships between the PPAR gamma gene polymorphisms and dietary intakes of meat, processed meat, milk and saturated fatty acids in Japanese with very low frequency of the Ala allele.