Up-Regulation of Interleukin-17 Expression by Human Papillomavirus Type 16 E6 in Nonsmall Cell Lung Cancer
Up-Regulation of Interleukin-17 Expression by Human Papillomavirus Type 16 E6 in Nonsmall Cell Lung Cancer
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DOI：
10.1002/cncr.25224
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发表时间：
2010-10-15
期刊：
影响因子：
6.2
通讯作者：
Shiau, Ming-Yuh
中科院分区：
文献类型：
--
作者：
Chang, Yih-Hsin;Yu, Chen-Wei;Shiau, Ming-Yuh
背景：人乳头瘤病毒（HPV）16/18感染与非吸烟肺癌相关。在这项研究中，作者调查了临床非小细胞肺癌（NSCLC）组织中白细胞介素（IL）-17表达与HPV感染之间的假定相关性，并检查了HPV感染对人NSCLC细胞系的影响。方法：采用免疫组化法检测79例NSCLC肿瘤组织中IL-17的表达。还检测了HPV 16/18 E6转染的H1299人NSCLC细胞的生长速率、IL-17 mRNA和分泌蛋白水平。研究结果：免疫组化数据显示，48.1%的肺肿瘤有IL-17染色，这与患者的性别（P= 0.03），HPV感染（P= 0.002）和肿瘤分期（P= 0.03）显著相关。IL-17与IL-6呈显著相关（P
BACKGROUND: Human papillomavirus (HPV) 16/18 infection is associated with nonsmoking lung cancer. In this study, the authors investigated a putative correlation between interleukin (IL)-17 expression and HPV infection in clinical nonsmall cell lung cancer (NSCLC) tissues and examined the effects of HPV infection on a human NSCLC cell line. METHODS: IL-17 expression was investigated in 79 NSCLC tumor tissues by immunohistochemistry. Growth rate, IL-17 mRNA, and secreting protein levels were also examined in HPV 16/18 E6-transfected H1299 human NSCLC cells. RESULTS: Immunohistochemical data showed that 48.1% of lung tumors had IL-17 staining, which was significantly associated with patients' sex (P=.03), HPV infection (P=.002), and tumor stage (P=.03). Significant correlations of IL-17 with IL-6 (P