Plasma fatty acid composition and 6-year incidence of hypertension in middle-aged adults - The Atherosclerosis Risk in Communities (ARIC) Study
Plasma fatty acid composition and 6-year incidence of hypertension in middle-aged adults - The Atherosclerosis Risk in Communities (ARIC) Study
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DOI：
10.1093/oxfordjournals.aje.a010038
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发表时间：
1999-09-01
影响因子：
5
通讯作者：
Eckfeldt, JH
中科院分区：
文献类型：
--
作者：
Zheng, ZJ;Folsom, AR;Eckfeldt, JH
在社区动脉粥样硬化风险 (ARIC) 研究 (1987-1995) 的明尼阿波利斯中年参与者中，研究了血浆胆固醇酯中基线脂肪酸组成与 6 年高血压发病率之间的关系。与从未患有高血压的人 (n = 1,975) 相比，高血压病患者 (n = 413) 的棕榈酸 (16:0) 和棕榈油酸 (16:1n7) 基线水平显着较高，但亚油酸 (18:2n6) 水平和多不饱和/饱和脂肪酸比 (P/S 比) 较低。在多不饱和脂肪酸中，与血压正常的人相比，高血压患者中二高-γ-亚麻酸 (20:3n6) 和花生四烯酸 (20:4n6) 的水平在统计学上显着较高。在单独模型中调整年龄、性别、体重指数、腰臀比、吸烟状况、乙醇摄入量、教育水平、体力活动和基线收缩压后，胆固醇酯中脂肪酸四分位间增量发生高血压的比值比估计为 1.26（95% 置信区间 (CI)：1.05、1.51），16:0、1.11（95% CI：0.96， 1.28) 对于 16:1n7、1.01 (95% CI: 0.85, 1.21) 对于 20:3n6、1.14 (95% CI: 1.03, 1.27) 对于 20:5n3、0.81 (95% CI: 0.68, 0.96) 对于 18:296 和 0.83 P/S 比（95% CI：0.70，0.99）。作者得出结论，亚油酸和 P/S 水平降低以及棕榈酸和花生四烯酸水平升高与高血压风险升高相关。
The association of baseline fatty acid composition in plasma cholesterol esters with 6-year incidence of hypertension was examined in middle-aged Minneapolis participants of the Atherosclerosis Risk in Communities (ARIC) Study (1987-1995). Compared with those who were never hypertensive (n = 1,975), incident hypertensives (n = 413) had statistically significantly higher baseline levels of palmitic (16:0) and palmitoleic (16:1n7) acids but lower levels of linoleic (18:2n6) acid and the polyunsaturated/saturated fatty acids ratio (P/S ratio). Among polyunsaturated fatty acids, levels of dihomo-gamma-linolenic (20:3n6) and arachidonic (20:4n6) acids were statistically significantly higher in incident hypertensives, compared with normotensives. After adjustment for age, sex, body mass index, waist/hip ratio, smoking status, ethanol intake, education level, physical activity, and baseline systolic blood pressure in separate models, the odds ratio estimates of incident hypertension for an interquartile increment of a fatty acid in cholesterol esters were 1.26 (95% confidence interval (CI): 1.05, 1.51) for 16:0, 1.11 (95% CI: 0.96, 1.28) for 16:1n7, 1.01 (95% CI: 0.85, 1.21) for 20:3n6, 1.14 (95% CI: 1.03, 1.27) for 20:5n3, 0.81 (95% CI: 0.68, 0.96) for 18:296, and 0.83 (95% CI: 0.70, 0.99) for the P/S ratio. The authors conclude that reduced levels of linoleic acid and the P/S ratio and elevated levels of palmitic and arachidonic acids are associated with a higher risk of hypertension.