Delayed Meal Timing, a Breakfast Skipping Model, Increased Hepatic Lipid Accumulation and Adipose Tissue Weight by Disintegrating Circadian Oscillation in Rats Fed a High-Cholesterol Diet.
Delayed Meal Timing, a Breakfast Skipping Model, Increased Hepatic Lipid Accumulation and Adipose Tissue Weight by Disintegrating Circadian Oscillation in Rats Fed a High-Cholesterol Diet.
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DOI：
10.3389/fnut.2021.681436
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发表时间：
2021
影响因子：
5
通讯作者：
Oda H
中科院分区：
文献类型：
--
作者：
Kim D;Hanzawa F;Sun S;Laurent T;Ikeda S;Umeki M;Mochizuki S;Oda H
背景：为了研究改变进食时间、不吃早餐是否会导致生物钟改变和脂代谢异常，我们建立了一种延迟进餐时间(DMT)的方案，即开始进食延迟4h。在本研究中，对照组和DMT大鼠分别在ZT 12-24和ZT 16-4期间饲喂高胆固醇饲料。DMT方案增加了肝脂和附睾脂组织重量，而不改变摄食量和体重。DMT组大鼠体温升高延迟4h，提示DMT后能量消耗减少。DMT使血清非酯化脂肪酸和胰岛素的昼夜节律峰值分别推迟2 h和4 h。DMT使肝脏新生脂肪酸合成基因表达的振荡峰延迟4h，而肝脏时钟基因的表达高峰延迟或不出现。虽然代谢振荡被认为是由时钟基因控制的，但在我们之前的研究中，没有观察到时钟基因和脂代谢相关基因之间的分解节律。这些数据表明，从头开始脂肪酸代谢的昼夜节律受进食时间的调节，但不受时钟基因的直接控制。目前的研究表明，不吃早餐会使脂肪肝和体内脂肪积累复杂化。
Background: To investigate whether shifted timing of eating, breakfast skipping, induces alterations in the circadian clock and abnormal lipid metabolism, we have established a delayed meal timing (DMT) protocol for rats, which started eating food 4 h delay. In the present study, control and DMT rats were fed a high-cholesterol diet during zeitgeber time (ZT) 12-24 and ZT 16-4, respectively. The DMT protocol increased the hepatic lipids and epididymal adipose tissue weight without changes in food intake and body weight. The surge in body temperature was delayed by 4 h in the DMT group, suggesting that energy expenditure was decreased in response to DMT. The peaks of the diurnal rhythm of serum non-esterified fatty acids and insulin were delayed by 2 and 4 h due to DMT, respectively. The oscillation peaks of hepatic de novo fatty acid synthesis gene expression was delayed by 4 h in response to DMT, whereas the peak of hepatic clock genes were 2 h delayed or not by DMT. Although metabolic oscillation is considered to be controlled by clock genes, the disintegration rhythms between the clock genes and lipid metabolism-related genes were not observed in rats fed a high-fat diet in our previous study. These data suggest that the circadian rhythm of de novo fatty acid metabolism is regulated by timing of eating, but is not directly controlled by clock genes. The present study suggests that breakfast skipping would complicate fatty liver and body fat accumulation.
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影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S
影响因子：
29
作者：
Adamovich Y;Rousso-Noori L;Zwighaft Z;Neufeld-Cohen A;Golik M;Kraut-Cohen J;Wang M;Han X;Asher G
通讯作者：
Asher G
影响因子：
3.5
作者：
Hughes ME;Hogenesch JB;Kornacker K
通讯作者：
Kornacker K
影响因子：
2.9
作者：
CHOMCZYNSKI, P;SACCHI, N
通讯作者：
SACCHI, N
影响因子：
29
作者：
Gachon, Federic;Olela, Fabienne Fleury;Schibler, Ueli
通讯作者：
Schibler, Ueli