Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men
Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men
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DOI：
10.1210/jc.2005-1097
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发表时间：
2006-01-01
影响因子：
5.8
通讯作者：
Ferrucci, L
中科院分区：
文献类型：
--
作者：
Maggio, M;Basaria, S;Ferrucci, L
内容：与年龄相关的睾酮（T）水平下降和促炎细胞因子增加导致老年男性慢性疾病。这些变化是否以及如何相关尚不清楚。目的：我们假设T和炎症标志物在老年男性中呈负相关。设计：这是一项横断面研究。设置：研究了一个基于人群的老年男性样本。参与者和测量：在排除服用糖皮质激素或抗生素或近期住院的参与者后，467名年龄在65岁或以上的男性，结果：在校正潜在混杂因素后，sIL-6 r与总T、生物可利用T、SHBG、白蛋白、IL-6、可溶性IL-6受体（sIL-6 r）、TNF-α、IL-1 β和C-反应蛋白呈显著负相关（P <0.05），而与总T、生物可利用T、SHBG、白蛋白、可溶性IL-6受体（sIL-6 r）、TNF-α、IL-1 β和C-反应蛋白呈显著负相关（P <0.05）。（r = -0.20; P < 0.001）和生物可利用T（r = -0.12; P < 0.05）。结论：这些初步研究结果表明，T和sIL-6 r之间呈负相关。需要进行纵向研究来确定这种关联的因果关系。
Context: An age-associated decline in testosterone (T) levels and an increase in proinflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear.Objective: We hypothesized that T and inflammatory markers are negatively correlated in older men.Design: This was a cross-sectional study.Setting: A population-based sample of older men was studied.Participants and Measures: After excluding participants taking glucocorticoids or antibiotics or those with recent hospitalization, 467 men, aged 65 yr or older, had complete determinations of total T, bioavailable T, SHBG, albumin, IL-6, soluble IL-6 receptor (sIL-6r), TNF-alpha, IL-1 beta, and C-reactive protein.Results: After adjusting for potential confounders, sIL-6r was significantly and inversely correlated with total T (r = -0.20; P < 0.001) and bioavailable T (r = -0.12; P < 0.05). T was not correlated with any other inflammatory marker.Conclusions: These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association.