New paradigms for functional HIV-specific nonneutralizing antibodies.
New paradigms for functional HIV-specific nonneutralizing antibodies.
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DOI：
10.1097/coh.0b013e328363d486
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发表时间：
2013-09
影响因子：
4.1
通讯作者：
Alter G
中科院分区：
文献类型：
--
作者：
Forthal D;Hope TJ;Alter G
虽然最近已经描述了大量新的广泛中和抗体，但是已经证明通过疫苗接种诱导这种抗体是困难的。相比之下，非中和抗体在感染早期出现，并反复与感染保护和疾病进展相关。我们开始对非中和抗体可能用来对抗艾滋病毒的更广泛的抗病毒机制有了新的认识，提供了前所未有的广泛方法来阻断和遏制艾滋病毒。在这篇综述中，我们总结了非中和抗体的特点，它们在HIV感染中的作用，以及新的范式转变功能，这些功能可能被下一代疫苗方法用于阻断HIV感染。
While a large number of novel broadly neutralizing antibodies has been recently described, the induction of such antibodies via vaccination has proven difficult. By contrast, non-neutralizing antibodies arise early during infection and have been repeatedly associated with both protection from infection and disease progression. We are beginning to gain new insights into the broader landscape of antiviral mechanisms that non-neutralizing antibodies may harness to fight HIV, providing an unprecedented breadth of approaches by which HIV can be blocked and contained. In this review we summarize the characteristics of non-neutralizing antibodies, their role in HIV infection, and new paradigm-shifting functions that may be exploited by next generation vaccine approaches aimed at blocking HIV infection.