IL-33: biological properties, functions, and roles in airway disease.
IL-33: biological properties, functions, and roles in airway disease.
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DOI：
10.1111/imr.12552
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发表时间：
2017-07
影响因子：
8.7
通讯作者：
Kita H
中科院分区：
文献类型：
--
作者：
Drake LY;Kita H
白细胞介素33(IL-33)是参与2型免疫和过敏性呼吸道疾病的关键细胞因子。IL-33在肺上皮细胞中大量表达，在粘膜器官的先天免疫反应和获得性免疫反应中发挥重要作用。在天然免疫中，IL-33和第二组天然淋巴样细胞(ILC2s)为快速免疫反应和组织动态平衡提供了重要的轴。在获得性免疫中，IL-33与树突状细胞、Th2细胞、滤泡T细胞和调节性T细胞相互作用，影响慢性呼吸道炎症和组织重塑的发展。过敏性呼吸道疾病患者IL-33和ILC2水平升高的临床研究结果表明，IL-33在这些疾病的发病机制中起重要作用。IL-33和ILC2也可作为疾病分类和监测疾病进展的生物标志物。本文综述了IL-33的生物学知识，并讨论了IL-33在调节呼吸道免疫反应和过敏性呼吸道疾病中的作用。
Interleukin (IL)-33 is a key cytokine involved in type 2 immunity and allergic airway diseases. Abundantly expressed in lung epithelial cells, IL-33 plays critical roles in both innate and adaptive immune responses in mucosal organs. In innate immunity, IL-33 and group 2 innate lymphoid cells (ILC2s) provide an essential axis for rapid immune responses and tissue homeostasis. In adaptive immunity, IL-33 interacts with dendritic cells, Th2 cells, follicular T cells, and regulatory T cells, where IL-33 influences the development of chronic airway inflammation and tissue remodeling. The clinical findings that both the IL-33 and ILC2 levels are elevated in patients with allergic airway diseases suggest that IL-33 plays an important role in the pathogenesis of these diseases. IL-33 and ILC2 may also serve as biomarkers for disease classification and to monitor the progression of diseases. In this article, we reviewed the current knowledge of the biology of IL-33 and discussed the roles of the IL-33 in regulating airway immune responses and allergic airway diseases.