Relationship between Eosinophilic and Neutrophilic Inflammation in Chinese Chronic Rhinosinusitis with Nasal Polyps
Relationship between Eosinophilic and Neutrophilic Inflammation in Chinese Chronic Rhinosinusitis with Nasal Polyps
复制标题
中国人慢性鼻窦炎伴鼻息肉嗜酸性粒细胞和中性粒细胞炎症的关系
DOI：
10.1159/000528946
复制
发表时间：
2023-02
影响因子：
2.8
通讯作者：
Yueqi Sun
中科院分区：
文献类型：
--
作者：
Ling Ma;Yunping Deng;Kanghua Wang;Jianbo Shi;Yueqi Sun
Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNPs) in China is characterized by a mixed eosinophilic-neutrophilic inflammation, linking to a more heterogeneous clinical phenotype. However, the relationship between eosinophilic and neutrophilic inflammation in Chinese patients with CRSwNP remains largely unknown. We aimed to further characterize the correlation between neutrophils with eosinophils in relation to clinical characters and disease control status after endoscopic sinus surgery (ESS). Methods: A total of 242 patients were recruited and stratified based on tissue (≥10%) eosinophilia and (≥20/per high-power field) neutrophilia. Clinical characteristics and disease control status were compared between subgroups. Associations between tissue eosinophils and neutrophils were analyzed. Results: The uncontrolled patients accounted for 41.3%, 41.3%, 17.1%, and 22.2% in subjects with concomitant tissue eosinophilia and neutrophilia (EN-high), isolated eosinophilia (E-high), isolated neutrophilia (N-high), and no eosinophilia and neutrophilia (EN-low), respectively. Positive correlations between tissue eosinophils and neutrophils were observed in patients with CRSwNP as well as in EN-high and N-high subgroups but not in E-high and EN-low subgroups. The EN-high subgroup had higher tissue eosinophil numbers than the other three subgroups. Both EN-high and E-high subgroups had higher rates of uncontrolled subjects than the N-high and EN-low subgroups; however, there was no difference in the rate of uncontrolled subjects between EN-high and E-high subgroups and between N-high and EN-low subgroups. Conclusion: Tissue neutrophils might have a potential interaction and mutual promotion effect with eosinophils in CRSwNP. However, tissue neutrophilia would not pose significant risk for poor disease control after ESS. Further larger, prospective studies are needed to confirm our findings.
登录
查看更多内容
慢性鼻窦炎流行病学：中国七个城市的横断面调查结果
影响因子：
12.4
作者：
Shi JB;Fu QL;Zhang H;Cheng L;Wang YJ;Zhu DD;Lv W;Liu SX;Li PZ;Ou CQ;Xu G
通讯作者：
Xu G
慢性鼻窦炎伴鼻息肉的细胞表型。
影响因子：
7.2
作者：
Lou, Hongfei;Meng, Yifan;Zhang, Luo
通讯作者：
Zhang, Luo
影响因子：
12.4
作者：
Hirsch AG;Stewart WF;Sundaresan AS;Young AJ;Kennedy TL;Scott Greene J;Feng W;Tan BK;Schleimer RP;Kern RC;Lidder A;Schwartz BS
通讯作者：
Schwartz BS
影响因子：
7.2
作者：
Fokkens, Wytske J.;Lund, Valerie J.;Wormald, Peter John
通讯作者：
Wormald, Peter John
中性粒细胞性慢性鼻窦炎伴鼻息肉 (CRSwNP) 中含有激活的吡啶结构域 3 (NLRP3) 炎性体
影响因子：
14.2
作者：
Wei, Yi;Zhang, Jia;Wen, Weiping
通讯作者：
Wen, Weiping