Global cerebral blood flow decreases during pain
Global cerebral blood flow decreases during pain
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DOI：
10.1097/00004647-199802000-00003
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发表时间：
1998-02-01
影响因子：
6.3
通讯作者：
Iadarola, MJ
中科院分区：
文献类型：
--
作者：
Coghill, RC;Sang, CN;Iadarola, MJ
正电子发射断层扫描研究已经确定了一组常见的被疼痛激活的大脑区域。然而，还没有研究对疼痛引起的脑血流变化进行定量检查。为了更好地表征疼痛期间的脑血流，14名受试者在休息、辣椒素引起的疼痛(250微克皮内注射)和无害振动时接受了正电子发射断层扫描。采用(H2O)-O-15静脉推注法结合动脉采血，定量评估整体脑血流变化。疼痛刺激导致全球脑血流量较静息水平下降22.8%(P<；0.0005)。这一下降不是由动脉二氧化碳分压或心率变化引起的。虽然确切的机制仍未确定，但这种由疼痛引起的整体下降代表了一种先前未知的CBF反应。
Positron emission tomography studies have identified a common set of brain regions activated by pain. No studies, however, have quantitatively examined pain-induced CBF changes. To better characterize CBF during pain, 14 subjects received positron emission tomography scans during rest, during capsaicin-evoked pain (250 mu g, intradermal injection), and during innocuous vibration. Using the (H2O)-O-15 intravenous bolus method with arterial blood sampling, global CBF changes were assessed quantitatively. Painful stimulation produced a 22.8% decrease in global CBF from resting levels (P < 0.0005). This decrease was not accounted for by arterial PCO2, or heart rate changes. Although the exact mechanism remains to be determined, this pain-induced global decrease represents a previously unidentified response of CBF.