VP2 SEQUENCES OF RECENT EUROPEAN VERY VIRULENT ISOLATES OF INFECTIOUS BURSAL DISEASE VIRUS ARE CLOSELY-RELATED TO EACH OTHER BUT ARE DISTINCT FROM THOSE OF CLASSICAL STRAINS
VP2 SEQUENCES OF RECENT EUROPEAN VERY VIRULENT ISOLATES OF INFECTIOUS BURSAL DISEASE VIRUS ARE CLOSELY-RELATED TO EACH OTHER BUT ARE DISTINCT FROM THOSE OF CLASSICAL STRAINS
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DOI：
10.1099/0022-1317-75-3-675
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发表时间：
1994-03-01
影响因子：
3.8
通讯作者：
SKINNER, MA
中科院分区：
文献类型：
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作者：
BROWN, MD;GREEN, P;SKINNER, MA
部分基因组片段A的5个最近的欧洲“非常毒力”（VV）分离的传染性法氏囊病病毒，编码的主要，构象，保护性表位，已被逆转录，扩增和克隆。对VP2基因582个碱基的序列分析表明，这4个U.K.分离株彼此密切相关，相差不超过两个碱基，但与“经典”1型菌株不同（与任何其它菌株相差至少29个碱基或4个氨基酸，与所有其它菌株的共有序列相差15个碱基或3个氨基酸）。英国分离物与来自荷兰的早期VV分离物的区别不超过五个碱基或两个氨基酸。英国分离株与最近发表的日本VV分离株的序列仅相差一个或两个碱基，没有氨基酸变化。
Part of genomic segment A of five recent European 'very virulent' (VV) isolates of infectious bursal disease virus, encoding the major, conformational, protective epitope, have been reverse-transcribed, amplified and cloned. Sequence analysis of 582 bases of VP2 showed that the four U.K. isolates are closely related to each other, differing by no more than two bases, but are distinct from the 'classical' type 1 strains (differing by at least 29 bases, or four amino acids, from any other strain and by 15 bases, or three amino acids, from the consensus sequence of all other strains). The U.K. isolates differ from an earlier VV isolate from the Netherlands by no more than five bases or two amino acids. The U.K. isolates differ by only one or two bases, with no amino acid changes, from the recently published sequence of a Japanese VV isolate.