Cross-talk between tumor cells and the microenvironment at the metastatic niche.
Cross-talk between tumor cells and the microenvironment at the metastatic niche.
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DOI：
10.2174/138920111798377058
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发表时间：
2011-10
影响因子：
2.8
通讯作者：
M. Carlini;M. D. De Lorenzo;L. Puricelli
中科院分区：
文献类型：
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作者：
M. Carlini;M. D. De Lorenzo;L. Puricelli
这篇综述介绍了有关转移前和转移阶段肿瘤细胞与转移靶器官微环境之间相互作用的最新信息。转移灶的发展不仅由肿瘤细胞的内在特性驱动，而且还由位于靶器官特定生态位的常驻细胞和外来细胞的相互作用驱动。原发肿瘤通过产生可溶性因子来调节转移靶点，这些因子动员来自远处器官（如骨髓）的细胞，进而定位在转移灶中。还有强有力的证据表明，一些原发性肿瘤甚至在播散性肿瘤细胞到达（转移前生态位）之前就在靶器官中为肿瘤细胞创造了肥沃的土壤。转移设定的玩家之间的关系是动态的，表现出高度的可塑性。肿瘤细胞通过获得遗传和/或表观遗传改变而发生变化，这些改变提供了适应性优势，并且转移生态位通过传入细胞类型或新分泌的可溶性介质进行重塑，从而建立了相互对话，激发了新水平的分子和细胞复杂性。揭示维持转移生态位的机制将有助于更好地了解播散性肿瘤细胞的生物学、设计新的治疗方法，并有望提高癌症患者的生存率。
This review presents recent information about the cross-talk between the tumor cells and the microenvironment in the target organ of metastasis at the premetastatic and metastatic stage. The development of metastatic foci is driven not only by the tumor cells intrinsic properties, but also by the interplay with resident and foreign cells located at particular niches in the target organ. The primary tumor modulates the metastatic target through the production of soluble factors that mobilize cells from distant organs like the bone marrow, which in turn localize in the metastatic niche. There is also strong evidence indicating that some primary tumors induce a fertile ground for the tumor cell at the target organ even before the arrival of the disseminated tumor cell (premetastatic niche). The relationship between the players of the metastatic setting is dynamic and shows a high degree of plasticity. Tumor cells change through the acquisition of genetic and/or epigenetic alterations that provide adaptive advantages and the metastatic niche is remodeled by incoming cell types or newly secreted soluble mediators, as a result a reciprocal dialogue is established that invokes new levels of molecular and cellular complexity. Unraveling the mechanisms that sustain the metastatic niche will allow a better understanding of the biology of the disseminated tumor cell, the design of new therapeutic approaches and, hopefully, the improvement of cancer patients' survival.