Acupuncture for chemotherapy-induced peripheral neuropathy (CIPN): a pilot study using neurography
Acupuncture for chemotherapy-induced peripheral neuropathy (CIPN): a pilot study using neurography
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DOI：
10.1136/acupmed-2011-010034
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发表时间：
2012-03-01
影响因子：
2.5
通讯作者：
Epplee, Susanne
中科院分区：
文献类型：
--
作者：
Schroeder, Sven;Meyer-Hamme, Gesa;Epplee, Susanne
目的 化疗引起的周围神经病变（CIPN）可产生严重的神经功能缺损和神经性疼痛，是终止或暂停化疗治疗的潜在原因。缺乏特异性和有效的治疗方法。方法进行了一项初步研究，通过神经传导研究（NCS）的变化来评估针灸对 CIPN 的治疗效果，其中 6 名患者在接受最佳医疗护理的基础上接受了 10 周的针灸治疗，另外 5 名对照患者接受了最佳医疗护理但没有对 CIPN 进行特异性治疗。结果 6 名接受针灸治疗的患者中有 5 名的 NCS 在治疗后有所改善。在对照组中，五名患者中的三名未显示出任何 NCS 差异，一名患者有所改善，一名患者的 NCS 受损。 结论 数据表明针灸对 CIPN 有积极作用。这项试点研究的令人鼓舞的结果证明了基于 NCS 的 CIPN 针灸随机对照试验的合理性。
Objectives Chemotherapy-induced peripheral neuropathy (CIPN) can produce severe neurological deficits and neuropathic pain and is a potential reason for terminating or suspending chemotherapy treatments. Specific and effective curative treatments are lacking.Methods A pilot study was conducted to evaluate the therapeutic effect of acupuncture on CIPN as measured by changes in nerve conduction studies (NCS) in six patients treated with acupuncture for 10 weeks in addition to best medical care and five control patients who received the best medical care but no specific treatment for CIPN.Results In five of the six patients treated with acupuncture, NCS improved after treatment. In the control group, three of five patients did not show any difference in NCS, one patient improved and one showed impaired NCS.Conclusion The data suggest that acupuncture has a positive effect on CIPN. The encouraging results of this pilot study justify a randomised controlled trial of acupuncture in CIPN on the basis of NCS.