Self-reported diseases and symptoms by rupture status among unselected Danish women with cosmetic silicone breast implants
Self-reported diseases and symptoms by rupture status among unselected Danish women with cosmetic silicone breast implants
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DOI：
10.1097/01.prs.0000041442.53735.f8
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发表时间：
2003-02-01
影响因子：
3.6
通讯作者：
Friis, S
中科院分区：
文献类型：
--
作者：
Hölmich, LR;Kjoller, K;Friis, S
流行病学证据不支持硅胶乳房植入物与结缔组织或其他风湿性疾病之间的联系。然而，最近的一项研究表明，植入物破裂的女性患纤维肌痛的风险可能会增加。根据乳房假体破裂情况，对238名接受美容硅胶乳房假体植入的丹麦女性进行了不良健康结局分析。根据磁共振成像，92名女性有明确的种植体破裂，146名女性种植体完好无损。在接受成像之前，这些妇女提供了血液样本，并完成了一份自填式问卷。对所有植入物破裂的妇女和有囊外破裂的亚组(n=23)与植入完整的妇女进行了比较，比较了一些自我报告的疾病和症状以及特定自身抗体的存在，如抗核抗体、类风湿因子、心磷脂免疫球蛋白G和M抗体。总体而言，在植入完整的植入物和植入破裂的植入物(包括囊外破裂)的妇女之间，自我报告的疾病或症状的发生或自身抗体的存在没有差异。唯一的例外是包膜痉挛，包膜外破裂的女性报告的发生率是完整植入物女性的6倍(OR，6.3；95%CI，1.7%至23.5)。总而言之，这项对未选择的接受硅胶乳房植入物的女性的研究可能没有建立硅胶假体破裂与结缔组织疾病或其他风湿性疾病相关的特定疾病或症状之间的联系，除了囊外破裂的女性中存在过度的包膜紧缩。
Epidemiologic evidence does not support an association between silicone breast implants and connective tissue or other rheumatic diseases. However, a recent study has suggested that women with ruptured implants may be at increased risk of developing fibromyalgia. An analysis of adverse health outcomes according to breast implant rupture status was conducted in 238 unselected Danish women with cosmetic silicone breast implants. Ninety-two of the women had definite implant rupture, and 146 had intact implants as determined by magnetic resonance imaging. Before undergoing imaging, the women provided blood samples and completed a self-administered questionnaire. Women with ruptured implants overall, and the subgroup with extracapsular ruptures (n = 23), were compared with women with intact implants regarding a number of self-reported diseases and symptoms and the presence of specific autoantibodies, such as antinuclear antibodies, rheumatoid factor, and cardiolipin immunoglobulin G and M antibodies. Overall, there were no differences in the occurrence of self-reported diseases or symptoms or in the presence of autoantibodies between women with intact implants and women with ruptured implants, including extracapsular rupture. The only exception was capsular contracture, which was reported six times more frequently by women with extracapsular ruptures than by women with intact implants (OR, 6.3; 95 percent CI, 1.7 to 23.5). In conclusion, this study of unselected women with silicone breast implants could establish no association between silicone implant rupture and specific diseases or symptoms related to connective tissue disease or other rheumatic conditions, except for an excess of capsular contracture among women with extracapsular rupture.