Helicobacter pylori and risk of gastroenteritis.
Helicobacter pylori and risk of gastroenteritis.
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幽门螺杆菌和胃肠炎的风险。
DOI：
10.1086/421705
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Parsonnet,Julie
中科院分区：
文献类型：
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作者：
Perry,Sharon;Sanchez,Luz;Yang,Shufang;Haggerty,ThomasD;Hurst,Philip;Parsonnet,Julie
背景。幽门螺杆菌感染被认为可以改变对胃肠炎的易感性。方法：对加利福尼亚北部有肠胃炎的家庭成员就其最近的发作进行了访谈，并对其进行了检测。幽门。采用条件logistic回归对继发性胃肠炎患者（病例）和无症状患者（对照组）相匹配的家庭中继发性胃肠炎的风险进行评估。病例和对照组也进行了甲型肝炎病毒（HAV）检测。在801户家庭中，205户（26%）至少有1名成员患有继发性胃肠炎，其中116户（56%）至少有1名成员无症状（158例和285例对照）。与未感染的成员相比，并根据年龄进行调整，只有1种感染抗体的人继发性胃肠炎的风险降低（优势比[OR]）。幽门感染，0.25[95%可信区间{CI}， 0.08-0.82]；HAV的OR为0.45 [95% CI, 0.23-0.87])。有两种抗体的。幽门螺杆菌和HAV没有增加这种负面影响（校正OR为0.39 [95% CI, 0.18-0.84]）。幽门螺杆菌并没有增加这些家庭患肠胃炎的风险。h。幽门感染和肠胃炎可能是由于先前暴露于其他肠道病原体和对其免疫所致。
Background.Helicobacter pylori infection is thought to modify susceptibility to gastroenteritis.Methods.Members of northern California households with an index case of gastroenteritis were interviewed regarding recent episodes and tested forH. pylori. Conditional logistic regression was used to evaluate the risk of secondary gastroenteritis within households matched for members with secondary gastroenteritis (cases) and those without symptoms (control subjects). Case and control subjects were also tested for hepatitis A virus (HAV).Results.Of 801 households, 205 (26%) had at least 1 member with secondary gastroenteritis, of which 116 (56%) also included at least 1 member without symptoms (158 case and 285 control subjects). Compared with uninfected members and adjusting for age, those with antibodies to only 1 infection were at a decreased risk of secondary gastroenteritis (odds ratio [OR] forH. pyloriinfection, 0.25 [95% confidence interval {CI}, 0.08–0.82]; OR for HAV, 0.45 [95% CI, 0.23–0.87]). Having antibodies to bothH. pyloriand HAV did not add to this negative effect (adjusted OR, 0.39 [95% CI, 0.18–0.84]).Conclusions.H. pyloridid not increase the risk of gastroenteritis in these households. A strong negative association betweenH. pyloriinfection and gastroenteritis is likely explained by prior exposure and immunity to other enteric pathogens.