Effect of aging on bladder function and the response to outlet obstruction in female rats
Effect of aging on bladder function and the response to outlet obstruction in female rats
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DOI：
10.1007/s002400050007
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发表时间：
2000-01-01
影响因子：
--
通讯作者：
Felsen, D
中科院分区：
文献类型：
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作者：
Kohan, AD;Danziger, M;Felsen, D
膀胱功能障碍在老年人群中是一个重要的问题。然而，在许多患者中伴随存在的其他疾病可能使其难以区分膀胱功能的变化和其他影响。本研究旨在研究老龄大鼠膀胱功能及部分膀胱出口梗阻（BOO）对膀胱功能的影响。在皮下植入Mediport导管后，对4个年龄组（6、12、18和24个月）的清醒雌性Fischer 344大鼠进行膀胱测量。在对照大鼠或经历三周BOG的大鼠中进行膀胱测量评价。膀胱顺应性显着下降，随着年龄的增长，这反映了阈值压力的增加，而膀胱容量的变化。部分BOO导致严重膀胱不稳定的发展。BOG后，所有年龄组的膀胱容量和顺应性均显著增加。除了6个月的大鼠外，阻塞动物的阈值压力较低。年轻的动物能够产生更高的收缩压力来补偿BOG，而年长的动物则不能。使用清醒模式的膀胱测压测量，我们已经证明，老化，本身可以影响膀胱功能。此外，老年动物对BOO的反应与年轻动物不同。这些结果表明，衰老和疾病都可能导致膀胱功能障碍，并表明膀胱功能障碍的治疗可能需要针对多种病因的治疗组合。
Bladder dysfunction in the aging population is a significant problem. However the concomitant presence of other diseases in many patients can make it difficult to distinguish between changes in bladder function and other influences. The present study was designed to study, in aging rats, bladder function and the effect of partial bladder outlet obstruction (BOO) on bladder function. Cystometrics were performed in awake, female Fischer 344 rats of four age groups (6, 12, 18 and 24 months) following subcutaneous implantation of a mediport catheter. Cystometric evaluations were carried out in control rats or those subject to three weeks of BOG. Bladder compliance significantly decreased with aging, which reflected an increase in threshold pressure without changes in bladder capacity. Partial BOO caused development of severe bladder instability. Following BOG, bladder capacity and compliance were significantly increased in all age groups. Threshold pressure was lower in obstructed animals, except for 6-month rats. Younger animals were able to generate a higher contraction pressure to compensate for the BOG, whereas older animals did not. Using an awake model of cystometric measurement, we have demonstrated that aging, by itself can affect bladder function. Furthermore, aged animals respond differently to BOO than younger animals. These results demonstrate that both aging and disease can contribute to bladder dysfunction, and suggest that treatment of bladder dysfunction may require a combination of therapies targeted to multiple etiologies.