Association of a genetic polymorphism of the E-cadherin gene with prostate cancer in a Japanese population
Association of a genetic polymorphism of the E-cadherin gene with prostate cancer in a Japanese population
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DOI：
10.1093/jjco/hyi040
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发表时间：
2005-03-01
影响因子：
2.4
通讯作者：
Ogawa, O
中科院分区：
文献类型：
--
作者：
Kamoto, T;Isogawa, Y;Ogawa, O
E-钙粘附素基因已被证实在细胞附着中具有生理作用，并被假设参与癌症的发生。5‘-非翻译区的多态(A到C替换)对E-钙粘蛋白基因的转录调控有直接影响。我们在日本人群中探索了E-钙粘素基因多态与前列腺癌风险之间的关系。研究对象包括236例前列腺癌患者、209例良性前列腺增生症(BPH)患者和139例男性对照组。前列腺癌患者与男性对照组之间差异有统计学意义(P=0.053)。前列腺癌患者与良性前列腺增生症患者之间无显著差异。将前列腺癌患者分为A+B期和C+D期，进展期前列腺癌患者(C+D期)与男性对照组比较差异有统计学意义(优势比=1.93，P=0.016)。一个A等位基因的存在可能导致癌症进展的风险增加。
The E-cadherin gene has been identified as having a physiological role in cellular attachment, and is hypothesized to participate in carcinogenesis. A polymorphism (an A to C substitution) in the 5'-untranslated region has a direct effect on E-cadherin gene transcriptional regulation. We explored the association between E-cadherin gene polymorphism and the risk of prostate cancer in a Japanese population. The subjects consisted of 236 patients with prostate cancer, 209 benign prostatic hyperplasia (BPH) patients and 139 male controls. A marginally significant difference was found between prostate cancer patients and male controls (P = 0.053). No significant difference was observed between prostate cancer and BPH patients. When patients with prostate cancer were divided into two groups, stage A+B and stage C+D, a significant difference was observed between progressive cancer patients (stage C+D) and male controls (odds ratio = 1.93, P = 0.016). It is possible that the presence of one A allele resulted in an increased risk of cancer progression.