Predictors of frailty in old age-results of a longitudinal study
Predictors of frailty in old age-results of a longitudinal study
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DOI：
10.1007/s12603-015-0634-5
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发表时间：
2016-11-01
影响因子：
5.8
通讯作者：
Konig, H. -H.
中科院分区：
文献类型：
--
作者：
Hajek, Andr;Brettschneider, C.;Konig, H. -H.
纵向研究老年虚弱的时间依赖性预测因子。基于人群的前瞻性队列研究。通过德国6个研究中心的全科医生办公室招募老年人。虚弱的过程被观察超过1.5年（第4波随访和第5波随访）1，602名80岁及以上的人（平均年龄85.4岁SD 3.2，平均CSHA CFS 3.5 SD 1.6）。采用加拿大健康与衰老临床虚弱量表评估虚弱程度（CSHA CFS），范围从1（非常健康）到7（严重虚弱）。固定效应回归显示，在总样本中，虚弱随着年龄的增加（=.2）以及抑郁症（=.5）和痴呆症（=.8）的发生而显著增加。婚姻状况和合并症的变化并不影响虚弱。虽然抑郁症和痴呆症的影响在女性中很明显，但这些影响在男性中没有达到统计学意义。我们的研究结果突出了衰老的作用以及痴呆症和抑郁症的发生。具体来说，为了延缓老年人的虚弱，制定干预策略来预防抑郁症可能是一种富有成效的方法。
To investigate time-dependent predictors of frailty in old age longitudinally.Population-based prospective cohort study.Elderly individuals were recruited via GP offices at six study centers in Germany. The course of frailty was observed over 1.5 years (follow up wave 4 and follow up wave 5).1,602 individuals aged 80 years and older (mean age 85.4 years SD 3.2, with mean CSHA CFS 3.5 SD 1.6) at follow up wave 4.Frailty was assessed by using the Canadian Study of Health and Aging Clinical Frailty Scale (CSHA CFS), ranging from 1 (very fit) to 7 (severely frail).Fixed effects regressions revealed that frailty increased significantly with increasing age (=.2) as well as the occurrence of depression (=.5) and dementia (=.8) in the total sample. Changes in marital status and comorbidity did not affect frailty. While the effects of depression and dementia were significant in women, these effects did not achieve statistical significance in men.Our findings highlight the role of aging as well as the occurrence of dementia and depression for frailty. Specifically, in order to delay frailty in old age, developing interventional strategies to prevent depression might be a fruitful approach.