Reproducibility of brain spectroscopy at 7T using conventional localization and spectral editing techniques.
Reproducibility of brain spectroscopy at 7T using conventional localization and spectral editing techniques.
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使用传统定位和光谱编辑技术在 7T 下脑光谱的再现性。
DOI：
10.1002/jmri.23997
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Barker,PeterB
中科院分区：
文献类型：
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作者：
Wijtenburg,SAndrea;Rowland,LauraM;Edden,RichardAE;Barker,PeterB
目的评价32通道头部线圈在7T时对前扣带回(AC)和背外侧前额叶皮质(DLPFC)区域光谱测量的重复性。材料和方法4名健康受试者分别使用刺激回声采集模式(STEAM)序列和Mega Press-IVS序列进行两次扫描，以编辑γ-氨基丁酸(GABA)。蒸汽光谱使用LC模型进行量化，而兆压IVS数据使用内部软件确定的峰值积分进行分析。结果对于AC STEAM数据集，N-乙酰天冬氨酸(NAA)、总肌酸(TCR)、总胆碱(Tcho)等显著代谢物的平均变异系数(CV)为6.2%，谷氨酸(Glu)、谷氨酰胺(Gln)、GABA等低信噪比(SNR)代谢物的平均CV为6.3%。对于DLPFC STEAM数据集，两次访问之间的平均变异系数分别为显著代谢物8.5%和低信噪比代谢物21%。在AC中，用STEAM序列和MEGA-PRESS-IVS序列测量GABA的重复性优于MEGA-PRESS-IVS序列(平均CV为3.5%比13.6%)，而在DLPFC区则相反(平均CV为16.2%比13.4%)。结论使用短TE STEAM序列和MEGA-PRESS-IVS序列对AC和DLPFC的7T磁共振波谱具有良好的重复性，包括GABA。J·马根。雷森。《成像》2013；38：460-467。©2012 Wiley期刊，Inc.
PurposeTo evaluate the reproducibility of spectroscopic measurements from the anterior cingulate (AC) and the dorsolateral prefrontal cortex (DLPFC) regions at 7T using a 32‐channel head coil.Materials and MethodsSpectra were acquired in four healthy subjects each scanned twice using a stimulated echo acquisition mode (STEAM) sequence, and a MEGA‐PRESS‐IVS sequence for gamma‐aminobutyric acid (GABA) editing. STEAM spectra were quantified using LCModel, whereas MEGA‐PRESS‐IVS data were analyzed using peak integrals determined using in‐house software. Mean coefficient of variation (CV) and mean absolute difference between visits were calculated.ResultsFor the AC STEAM dataset, the mean CV between visits was 6.2% for prominent metabolites such as N‐acetylaspartate (NAA), total creatine (tCr), and total choline (tCho) and 6.3% for low signal‐to‐noise ratio (SNR) metabolites such as glutamate (Glu), glutamine (Gln), and GABA. The mean CV between visits for the DLPFC STEAM dataset was 8.5% for prominent metabolites and 21% for lower SNR metabolites. In the AC, the reproducibility measures for GABA were superior for STEAM compared to MEGA‐PRESS‐IVS (mean CV of 3.5% vs. 13.6%), but the opposite pattern was observed in the DLPFC region (mean CV of 16.2% vs. 13.4%).Conclusion7T MR spectroscopy of the AC and DLPFC using both short TE STEAM and MEGA‐PRESS‐IVS sequences provide excellent reproducibility of 12 metabolites, including GABA. J. Magn. Reson. Imaging 2013;38:460–467. © 2012 Wiley Periodicals, Inc.