Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.
Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.
复制标题
DOI：
10.1016/j.ebiom.2020.102824
复制
发表时间：
2020-06
期刊：
影响因子：
11.1
通讯作者：
David R. Rawnsley;A. Diwan
中科院分区：
文献类型：
--
作者：
David R. Rawnsley;A. Diwan
肥胖是一种全球性流行病，导致代谢综合征、糖尿病、脂肪肝、心脑血管疾病、阿尔茨海默病和某些癌症等多种疾病的患病率不断上升。由于肥胖仍然是一个棘手的问题，因此需要一种新的紧迫感，尽管行为、药物和手术方法的迅速扩张无法带来持久的结果。
Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers. A renewed sense of urgency is required as obesity remains an intractable problem, despite a rapidly expanding armamentarium of behavioral, pharmacologic and surgical approaches which fall short of delivering sustained results