Association of Sleep Duration with Mortality from Cardiovascular Disease and Other Causes for Japanese Men and Women: the JACC Study
Association of Sleep Duration with Mortality from Cardiovascular Disease and Other Causes for Japanese Men and Women: the JACC Study
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DOI：
10.1093/sleep/32.3.295
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发表时间：
2009-03-01
期刊：
影响因子：
5.6
通讯作者：
Temakoshi, Akiko
中科院分区：
文献类型：
--
作者：
Ikehara, Satoyo;Iso, Hiroyasu;Temakoshi, Akiko
研究目的：检验睡眠时间与心血管疾病和其他原因死亡率之间的性别相关性。设计：队列研究。设置：社区研究。参与者：从1988年到1990年，共有98,634名年龄在40岁到79岁之间的受试者(41,489名男性和57,145名女性)，并被跟踪到2003年。干预：不适用。测量和结果：在14.3年的中位随访期中，有1964人(男性和女性：1038和926)死于中风，881人(508和373)死于冠心病，4287人(2297和1990)死于心血管疾病，5465人(3432和2033)死于癌症和2033以及14,540人(8548人和5992人)。与睡眠时间为7小时相比，睡眠时间为4小时或更少的女性因冠心病和非心血管疾病/非癌症以及所有原因导致的死亡率增加，无论男女。女性冠心病为2.32(1.19~4.50)，非心血管疾病/非癌症为1.49(1.02~2.18)和1.47(1.01~2.15)，男性为1.29(1.02~1.64)，女性为1.28(1.03~1.60)。与男性和女性睡眠7小时相比，长达10小时或更长时间的睡眠时间与男性和女性因完全和缺血性中风、完全心血管疾病、非心血管疾病/非癌症以及所有原因导致的死亡率增加1.5%至2倍有关。结论：短睡眠时间和长睡眠时间均与心血管疾病、非心血管疾病/非癌症和各种原因的死亡率增加有关，两者与总死亡率呈U型关系，睡眠时间在7小时时最低。
Study Objectives: To examine sex-specific associations between sleep duration and mortality from cardiovascular disease and other causes.Design: Cohort study.Setting: Community-based study.Participants: A total of 98,634 subjects (41,489 men and 57,145 women) aged 40 to 79 years from 1988 to 1990 and were followed until 2003.Interventions: N/A.Measurements and Results: During a median follow-up of 14.3 years, there were 1964 deaths (men and women: 1038 and 926) from stroke, 881 (508 and 373) from coronary heart disease, 4287 (2297 and 1990) from cardiovascular disease, 5465 (3432 and 2033) from cancer, and 14,540 (8548 and 5992) from all causes. Compared with a sleep duration of 7 hours, sleep duration of 4 hours or less was associated with increased mortality from coronary heart disease for women and noncardiovascular disease/noncancer and all causes in both sexes. The respective multi-variable hazard ratios were 2.32 (1.19-4.50) for coronary heart disease in women, 1.49 (1.02-2.18) and 1.47 (1.01-2.15) for noncardiovascular disease/noncancer, and 1.29 (1.02-1.64) and 1.28 (1.03-1.60) for all causes in men and women, respectively. Long sleep duration of 10 hours or longer was associated with 1.5- to 2-fold increased mortality from total and ischemic stroke, total cardiovascular disease, noncardiovascular disease/noncancer, and all causes for men and women, compared with 7 hours of sleep in both sexes. There was no association between sleep duration and cancer mortality in either sex.Conclusions: Both short and long sleep duration were associated with increased mortality from cardiovascular disease, noncardiovascular disease/noncancer, and all causes for both sexes, yielding a U-shaped relationship with total mortality with a nadir at 7 hours of sleep.